Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma.
Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma.
复制标题
支气管癌中的铃蟾肽、生长抑素和神经降压素样免疫反应性。
DOI：
10.1210/jcem-53-6-1310
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
S. R. Bloom
中科院分区：
文献类型：
--
作者：
S. Wood;J. Wood;M. Ghatei;Y. Lee;D. O’Shaughnessy;S. R. Bloom
蛙皮素是一种在成人肺中发现的调节肽，在胎儿肺发育期间浓度较高，具有有效的生物学作用，包括刺激多种激素释放的能力。从支气管癌患者的肿瘤，肺和血浆的提取物的放射免疫分析显示非常高的组织蛙皮素浓度在两个燕麦细胞癌，与较低的水平，在两个六个腺癌超过正常肺中发现的浓度。燕麦细胞癌也含有大量的生长抑素和神经降压素。神经降压素进一步检测到两个七个鳞状细胞癌和三个腺癌。支气管癌分泌的调节肽可能解释了一些不清楚的非转移性临床表现。
Bombesin, a regulatory peptide found in adult lung and in higher concentration during development in the foetal lung, has potent biological actions which include the ability to stimulate the release of a number of hormones. Radioimmunoassay of extracts of tumour, lung and plasma from patients with bronchial carcinoma revealed very high tissue bombesin concentrations in two oat cell carcinomas, with lower levels in two out of six adenocarcinomas exceeding the concentrations found in normal lung. The oat cell carcinomas also contained significant amounts of somatostatin and in one case neurotensin. Neurotensin was further detected in two out of seven squamous tumours and three adenocarcinomas. Secretion of regulatory peptides by bronchial carcinomas may account for some of their ill-understood non-metastatic clinical manifestations.