Chronic fatigue syndrome, the immune system and viral infection
Chronic fatigue syndrome, the immune system and viral infection
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DOI：
10.1016/j.bbi.2011.06.016
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发表时间：
2012-01-01
影响因子：
15.1
通讯作者：
Ford, B.
中科院分区：
文献类型：
--
作者：
Bansal, A. S.;Bradley, A. S.;Ford, B.
慢性疲劳综合征（CFS），根据最近的标准定义，是一种异质性疾病，具有一组常见的症状，通常伴随病毒感染或一段时间的压力。尽管多年的深入研究，但在这种情况下免疫功能障碍的存在，性质和程度上几乎没有共识。然而，可能存在炎症和促炎细胞因子（如白细胞介素（IL）1、IL 6和肿瘤坏死因子（TNF）α）的参数略微增加。此外，受损的自然杀伤细胞功能似乎很明显。T细胞数量的改变已经被一些人描述，而不是其他人。虽然常见疱疹病毒的阳性血清学流行率似乎与健康对照组没有什么不同，但有一些证据表明病毒持续存在且病毒复制的遏制不足。某些疱疹病毒损害T细胞记忆发育的能力可以解释这种病毒持续存在和症状持续的原因。基于这种理解的新疗法比现有方法更有可能产生益处。(C)2011 Elsevier Inc. All rights reserved.
The chronic fatigue syndrome (CFS), as defined by recent criteria, is a heterogeneous disorder with a common set of symptoms that often either follows a viral infection or a period of stress. Despite many years of intense investigation there is little consensus on the presence, nature and degree of immune dysfunction in this condition. However, slightly increased parameters of inflammation and pro-inflammatory cytokines such as interleukin (IL) 1, IL6 and tumour necrosis factor (TNF) alpha are likely present. Additionally, impaired natural killer cell function appears evident. Alterations in T cell numbers have been described by some and not others. While the prevalence of positive serology for the common herpes viruses appears no different from healthy controls, there is some evidence of viral persistence and inadequate containment of viral replication. The ability of certain herpes viruses to impair the development of T cell memory may explain this viral persistence and the continuation of symptoms. New therapies based on this understanding are more likely to produce benefit than current methods. (C) 2011 Elsevier Inc. All rights reserved.