Epigenetics of human papillomaviruses.
Epigenetics of human papillomaviruses.
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DOI：
10.1016/j.virol.2013.07.016
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发表时间：
2013-10
期刊：
影响因子：
3.7
通讯作者：
Lambert PF
中科院分区：
文献类型：
--
作者：
Johannsen E;Lambert PF
人乳头瘤病毒（HPV）是感染皮肤或粘膜上皮的常见人类病原体，其中它们引起疣，通常消退的独立良性病变。HPV的生命周期与其感染的宿主上皮细胞的分化密切相关。嗜粘膜HPV是人类已知的最常见的性传播病原体。亲粘膜HPV的一个亚组，所谓的高风险HPV，在病因学上与肛门生殖道的许多癌症相关，最显著的是宫颈癌，以及越来越多的头颈癌。在这些癌症中，通常存在双链环状核质粒的HPV基因组通常被发现整合到宿主基因组中，并表达两种病毒致癌基因E6和E7，这两种基因与这些高风险HPV引起的癌症的发展和复发有关。许多研究，主要是关于高危HPV 16的研究，已经证明病毒基因组的甲基化状态不仅在病毒生命周期的背景下发生变化，而且在以癌症为高潮的进行性肿瘤疾病的背景下发生变化。在这篇文章中，我们总结了从这些研究中获得的知识。我们还提供了第一次分析可用的ChIP-seq数据的表观遗传修饰的组蛋白以及转录因子在高危HPV 18基因组中的HeLa细胞，宫颈癌衍生的细胞系的背景下的占用一直是使用这种技术进行广泛分析的主题。
Human papilllomaviruses (HPVs) are common human pathogens that infect cutaneous or mucosal epithelia in which they cause warts, self-contained benign lesions that commonly regress. The HPV life cycle is intricately tied to the differentiation of the host epithelium it infects. Mucosotropic HPVs are the most common sexually transmitted pathogen known to mankind. A subset of the mucosotropic HPVs, so-called high risk HPVs, is etiologically associated with numerous cancers of the anogenital tract, most notably the cervix, as well as a growing fraction of head and neck cancers. In these cancers, the HPV genome, which normally exists an a double stranded, circular, nuclear plasmid, is commonly found integrated into the host genome and expresses two viral oncogenes, E6 and E7, that are implicated in the development and maintainance of the cancers caused by these high risk HPVs. Numerous studies, primarily on the high risk HPV16, have documented that the methylation status of the viral genome changes not only in the context of the viral life cycle but also in the context of the progressive neoplastic disease that culminates in cancer. In this article, we summarize the knowledge gained from those studies. We also provide the first analysis of available ChIP-seq data on the occupancy of both epigentically modified histones as well as transcription factors on the high risk HPV18 genome in the context of HeLa cells, a cervical cancer-derived cell line that has been the subject of extensive analyses using this technique.
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