Twenty-four-hour energy expenditure in Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus
Twenty-four-hour energy expenditure in Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus
复制标题
患有 2 型（非胰岛素依赖型）糖尿病的皮马印第安人 24 小时能量消耗
作者：
A. Fontvieille;Stephen Lillioja;R. Ferraro;L. O. Schulz;R. Rising;Eric Ravussin
总结评估类型2的影响在呼吸室中测定了151名皮马印第安人和102名糖耐量正常的非胰岛素依赖型糖尿病患者的能量代谢、24小时能量消耗、基础代谢率和睡眠代谢率（67例男性/35例女性，（平均值± SD）28±7岁，99±24 kg，32±9%体脂）和49例2型糖尿病患者（22名男性/27名女性，35±11岁，107±33 kg，39±7%体脂），在维持体重饮食至少3天后。在调整了去脂体重、脂肪量、年龄和性别的差异后，糖尿病患者的24小时能量消耗、基础代谢率和睡眠代谢率显著高于对照组（分别为72千卡/天，p<0.05; 99千卡/天，p<0.005; 99千卡/天，p<0.001）。两组的自发体力活动相似，而食物的热效应，计算为全天活动校正的平均能量消耗高于睡眠代谢率，并表示为能量摄入的百分比，在2型糖尿病患者中显著较低（17.1±7.1 vs 19.8± 5.6%，p<0.05）。24小时能量消耗校正值、基础代谢率和睡眠代谢率与肝脏内源性葡萄糖生成相关（分别为r=0.22，p<0.05; r=0.22，p<0.05; r=0.31，p<0.01）。因此，基础代谢率和睡眠代谢率增加，导致24小时久坐能量消耗增加，可能在2型糖尿病受试者中经常观察到的体重减轻中起作用，此外还有糖尿引起的能量损失。
SummaryTo assess the impact of Type 2 (non-insulin-dependent) diabetes mellitus on energy metabolism, 24-h energy expenditure, basal metabolic rate and sleeping metabolic rate were measured in a respiratory chamber in 151 Pima Indians, 102 with normal glucose tolerance (67 male/35 female, (mean ± SD) 28±7 years, 99±24 kg, 32±9% body fat) and in 49 with Type 2 diabetes (22 male/27 female, 35±11 years, 107±33 kg, 39±7% body fat), after at least 3 days on a weight maintaining diet. After adjustment for differences in fat-free mass, fat mass, age and sex, 24-h energy expenditure, basal metabolic rate and sleeping metabolic rate were significantly higher in diabetic patients than in control subjects (72 kcal/day, p<0.05; 99 kcal/day, p<0.005; 99 kcal/day, p<0.001 respectively). Spontaneous physical activity was similar in both groups whereas the thermic effect of food, calculated as the mean energy expenditure corrected for activity throughout the day above sleeping metabolic rate and expressed as a percentage of energy intake, was significantly lower in Type 2 diabetic patients (17.1±7.1 vs 19.8±5.6%, p<0.05). Adjusted values of 24-h energy expenditure, basal metabolic rate and sleeping metabolic rate were correlated with hepatic endogenous glucose production (r=0.22, p<0.05; r=0.22, p<0.05; r=0.31, p<0.01 respectively). Therefore, increased basal and sleeping metabolic rates, resulting in increased 24-h sedentary energy expenditure may play a role in the weight loss so often observed in Type 2 diabetic subjects in addition to the energy loss from glycosuria.
影响因子：
15.9
作者：
CONSOLI, A;NURJHAN, N;GERICH, JE
通讯作者：
GERICH, JE
影响因子：
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作者：
SCHOELLER, DA;RAVUSSIN, E;JEQUIER, E
通讯作者：
JEQUIER, E