Genetic variation in adaptability and pleiotropy in budding yeast
Genetic variation in adaptability and pleiotropy in budding yeast
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DOI：
10.7554/elife.27167
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发表时间：
2017-08-17
期刊：
影响因子：
7.7
通讯作者：
Desai, Michael M.
中科院分区：
文献类型：
--
作者：
Jerison, Elizabeth R.;Kryazhimskiy, Sergey;Desai, Michael M.
进化有利于适应性更强的生物，只要适应性存在遗传变异。在这里，我们量化了230个后代之间的交叉分歧酵母菌株的这种变化。我们测量每个后代基因型的适应性，定义为在特定环境条件下的平均适应率，并分析该性状的遗传力，可预测性和遗传基础。我们发现，初始基因型强烈影响适应性，可以改变未来进化的遗传基础。初始基因型也会影响适应适应不同环境的多效性结果。适应性和多效性的遗传变异很大程度上取决于初始适应度，根据适应性随着初始适应度的增加而下降的规则，但几个单独的QTL也具有显着的特异性作用。我们的研究结果表明，适应性和多效性是复杂的性状，广泛的遗传差异所产生的自然发生的变化。
Evolution can favor organisms that are more adaptable, provided that genetic variation in adaptability exists. Here, we quantify this variation among 230 offspring of a cross between diverged yeast strains. We measure the adaptability of each offspring genotype, defined as its average rate of adaptation in a specific environmental condition, and analyze the heritability, predictability, and genetic basis of this trait. We find that initial genotype strongly affects adaptability and can alter the genetic basis of future evolution. Initial genotype also affects the pleiotropic consequences of adaptation for fitness in a different environment. This genetic variation in adaptability and pleiotropy is largely determined by initial fitness, according to a rule of declining adaptability with increasing initial fitness, but several individual QTLs also have a significant idiosyncratic role. Our results demonstrate that both adaptability and pleiotropy are complex traits, with extensive heritable differences arising from naturally occurring variation.