Autism spectrum disorder prevalence and proximity to industrial facilities releasing arsenic, lead or mercury.
Autism spectrum disorder prevalence and proximity to industrial facilities releasing arsenic, lead or mercury.
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DOI：
10.1016/j.scitotenv.2015.07.024
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发表时间：
2015-12-01
期刊：
影响因子：
--
通讯作者：
Baio J
中科院分区：
文献类型：
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作者：
Dickerson AS;Rahbar MH;Han I;Bakian AV;Bilder DA;Harrington RA;Pettygrove S;Durkin M;Kirby RS;Wingate MS;Tian LH;Zahorodny WM;Pearson DA;Moyé LA 3rd;Baio J
产前和围产期暴露于空气污染物已被证明对后代的出生结果产生不利影响，并可能导致自闭症谱系障碍（ASD）的患病率。对于这项生态学研究，我们评估了ASD患病率之间的关联，在人口普查区的水平，并接近道质心最近的工业设施释放砷，铅或汞在20世纪90年代。我们使用2000年至2008年的自闭症和发育障碍监测（ADDM）网络的五个站点的监测数据和2000年的人口普查数据来估计患病率。根据美国环境保护署有毒物质释放清单（USEPA-TRI），使用多水平负二项回归模型来测试ASD患病率与1991年至1999年存在的工业设施之间的关联。2489个人口普查区的数据显示，在调整人口统计学和社会经济区域特征后，ASD患病率在最近的第10百分位数的人口普查区比在最远的第50百分位数的人口普查区更高（调整后的RR = 1.27，95%CI：（1.00，1.61），P = 0.049）。这项研究中观察到的结果表明，城市居民接近排放空气污染物的工业设施与ASD患病率较高之间存在关联。
Prenatal and perinatal exposures to air pollutants have been shown to adversely affect birth outcomes in offspring and may contribute to prevalence of autism spectrum disorder (ASD). For this ecologic study, we evaluated the association between ASD prevalence, at the census tract level, and proximity of tract centroids to the closest industrial facilities releasing arsenic, lead or mercury during the 1990s. We used 2000 to 2008 surveillance data from five sites of the Autism and Developmental Disabilities Monitoring (ADDM) network and 2000 census data to estimate prevalence. Multi-level negative binomial regression models were used to test associations between ASD prevalence and proximity to industrial facilities in existence from 1991 to 1999 according to the US Environmental Protection Agency Toxics Release Inventory (USEPA-TRI). Data for 2489 census tracts showed that after adjustment for demographic and socio-economic area-based characteristics, ASD prevalence was higher in census tracts located in the closest 10th percentile compared of distance to those in the furthest 50th percentile (adjusted RR = 1.27, 95% CI: (1.00, 1.61), P = 0.049). The findings observed in this study are suggestive of the association between urban residential proximity to industrial facilities emitting air pollutants and higher ASD prevalence.