The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40 000 subjects
The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40 000 subjects
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DOI：
10.1046/j.1365-2036.2003.01456.x
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发表时间：
2003-03-01
影响因子：
7.6
通讯作者：
Mearin, F
中科院分区：
文献类型：
--
作者：
Hungin, APS;Whorwell, PJ;Mearin, F
目的：为了确定肠易激综合征的患病率，症状模式和影响，在八个欧洲国家，使用标准化的methodology.Methods：一个社区调查的41 984个人进行了使用配额抽样和随机数字电话拨号，以确定那些诊断为肠易激综合征或那些符合诊断标准，随后进行深入的访谈。总体患病率为11.5%（6.2-12%）; 9.6%有当前症状，4.8%已被正式诊断，另有2.9%、4.2%和6.5%分别符合罗马II、罗马I或曼宁标准。排便习惯分类因标准而异：罗马II的63%有“交替”排便习惯，自我报告的21%。平均而言，69%的人报告症状持续1小时，每天两次，每月7天。肠易激综合征患者报告更多的消化性溃疡（13%对6%），反流（21%对7%）和阑尾切除术（17%对11%），但不是子宫切除术，胆囊切除术或膀胱手术。90%的人在初级保健中咨询，17%在医院咨询; 69%使用药物。肠易激综合征实质上干扰了生活方式，并造成abouteis.Conclusions：肠易激综合征是常见的生活方式和保健的主要影响。大多数病例未得到诊断，各国之间的流行率差异很大。诊断标准与不同的患病率和排便习惯亚型有关。这限制了它们在临床实践中的实用性和使用它们的研究结果的可转移性。
Aim: To determine the prevalence, symptom pattern and impact of the irritable bowel syndrome, across eight European countries, using a standardized methodology.Methods: A community survey of 41 984 individuals was performed using quota sampling and random digit telephone dialling to identify those with diagnosed irritable bowel syndrome or those meeting diagnostic criteria, followed by in-depth interviews.Results: The overall prevalence was 11.5% (6.2-12%); 9.6% had current symptoms, 4.8% had been formally diagnosed and a further 2.9%, 4.2% and 6.5% met the Rome II, Rome I or Manning criteria, respectively. Bowel habit classification varied by criteria: 63% had an 'alternating' bowel habit by Rome II vs. 21% by self-report. On average, 69% reported symptoms lasting for 1 h, twice daily, for 7 days a month. Irritable bowel syndrome sufferers reported more peptic ulcer (13% vs. 6%), reflux (21% vs. 7%) and appendectomy (17% vs. 11%), but not hysterectomy, cholecystectomy or bladder procedures. Ninety per cent had consulted in primary care and 17% in hospital; 69% had used medication. Irritable bowel syndrome substantially interfered with lifestyle and caused absenteeism.Conclusions: Irritable bowel syndrome is common with major effects on lifestyle and health care. The majority of cases are undiagnosed and the prevalence varies strikingly between countries. Diagnostic criteria are associated with varying prevalences and bowel habit sub-types. This limits their utility in clinical practice and the transferability of research findings using them.