Computer-Assisted Three-Dimensional Analysis of Multifocal/Multicentric Prostate Cancer
Computer-Assisted Three-Dimensional Analysis of Multifocal/Multicentric Prostate Cancer
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DOI：
10.3109/07357907.2014.911878
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发表时间：
2014-08-01
影响因子：
2.4
通讯作者：
Konishi, Noboru
中科院分区：
文献类型：
--
作者：
Fujii, Tomomi;Ishida, Eiwa;Konishi, Noboru
为了研究多个邻近的前列腺癌病变，我们构建了计算机辅助的前列腺癌根治术标本的三维模型。然后，我们通过DNA微阵列分析检测了样本之间的遗传异质性。高Gleason模式的癌灶是从头开始发生的，而低Gleason模式的癌灶与低Gleason模式的癌症是连续发生的。三维分析显示，不同的、不连续的癌灶在遗传上是独立的、多中心的。相反，一些邻近的多灶性病变具有相同的遗传来源。
In order to study multiple contiguous prostate cancer lesions, we constructed computer-assisted, three-dimensional models of multifocal prostate cancer specimens obtained by radical prostatectomy. We then examined the genetic heterogeneity among the specimens by DNA microarray analysis. Cancer foci with high Gleason patterns were found to occur de novo, whereas those with low Gleason patterns occurred contiguously with cancers of low Gleason patterns. Three-dimensional analysis showed that distinct, noncontiguous cancerous foci were genetically independent andmulticentric. In contrast some contiguous multifocal lesions had the same genetic origin.