Measuring oxygen saturation of skin with advancing age using iterative optical path-length matrix method
Measuring oxygen saturation of skin with advancing age using iterative optical path-length matrix method
复制标题
使用迭代光程长度矩阵法测量随年龄增长的皮肤氧饱和度
DOI：
10.1007/s10015-013-0111-3
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发表时间：
2013
影响因子：
0.9
通讯作者：
Keiko Ogawa
中科院分区：
文献类型：
--
作者：
Satoshi Yamamoto;Shumpei Watanabe;Izumi Fujiwara;N. Tsumura;Tetsuo Akiba;Keiko Ogawa
我们通过迭代我们以前提出的方法，可以快速地模拟皮肤光谱反射率与高精度测量在不同年龄的皮肤的氧饱和度。氧饱和度通常通过脉搏血氧仪测量，以评估氧气输送，以监测特定时间的心肺功能。另一方面，预计皮肤的氧饱和度可以评估外周状况。我们之前提出的方法，光程长度矩阵法（OPLM），是基于多层组织（MCML）中稳态光传输的蒙特卡罗模型，但可以模拟皮肤光谱反射比MCML快27，000倍。在这项研究中，我们实现了一个迭代的OPLM与非线性优化技术，这种方法也可以用于估计血红蛋白浓度和氧饱和度从测量的皮肤光谱反射率。迭代OPLM比MCML快25，000倍以上，准确率为95%。在临床测量之前，确定血氧饱和度在测量压力之间的稳定性。然后，用分光光度计测量了72名年龄在20 - 86岁之间的门诊患者的皮肤反射光谱。每个受试者测量三个点：前臂、鱼际隆起和中间指骨。结果表明，皮肤血氧饱和度随年龄变化，各点基本保持不变。
We measured the oxygen saturation of skin at various ages by iterating our previously proposed method that can rapidly simulate skin spectral reflectance with high accuracy. Oxygen saturation is commonly measured by a pulse oximeter to evaluate oxygen delivery for monitoring the functions of heart and lungs at a specific time. On the other hand, oxygen saturation of skin is expected to assess peripheral conditions. Our previously proposed method, the optical path-length matrix method (OPLM), is based on a Monte Carlo model of steady-state light transport in multi-layered tissue (MCML), but can simulate skin spectral reflectance 27,000 times faster than MCML. In this study, we implemented an iterative OPLM with a nonlinear optimization technique such that this method can also be used for estimating hemoglobin concentration and oxygen saturation from the measured skin spectral reflectance. The iterative OPLM was over 25,000 times faster than the MCML with 95 % accuracy. Before measurements in clinic, stability of oxygen saturation among measuring pressure was confirmed. Then, the skin reflectance spectra of 72 outpatients aged between 20 and 86 years were measured by a spectrophotometer. Three points were measured for each subject: the forearm, the thenar eminence, and the intermediate phalanx. The result showed that the oxygen saturation of skin remained constant at each point as the age varied.