Variations in transforming growth factor beta in human milk are not related to levels in plasma
Variations in transforming growth factor beta in human milk are not related to levels in plasma
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DOI：
10.1006/cyto.2002.0987
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发表时间：
2002-02-21
期刊：
影响因子：
3.8
通讯作者：
Gibson, RA
中科院分区：
文献类型：
--
作者：
Hawkes, JS;Bryan, DL;Gibson, RA
来自个体女性的人乳中转化生长因子β（TGF β）的浓度存在相当大的差异，这不容易用诸如吸烟或疾病等母体因素来解释。一种潜在的相关性是母亲的TGF β血浆水平，因为已经充分记录了响应于许多病理状况的TGF β血浆浓度的变化。本研究的目的是调查在同一天从80名哺乳期母亲在产后5周的人乳和血浆中获得的单一样品中TGF β 1和TGF β 2的浓度之间的关系。人乳水性部分中TGF β 1和TGF β 2的浓度范围为228至3542 pg/ml（647，438-799;中位数，第25 - 75个月）和98 - 13 855 pg/ml（955，535-1999）和配对血浆样本分别为440 - 19 460（4026，3245 - 4656）和92 - 1739（620，391-925）。因此，在牛奶中，TGF β 1与TGF β 2的中位比例为1：1.6，而血浆中相应的中位比例为7：1。牛奶中TGF β的任一种亚型的浓度与血浆中相应的TGF β浓度之间没有相关性。(C)2002爱思唯尔科技有限公司。保留所有权利。
There is considerable variability in the concentrations of transforming growth factor beta (TGFbeta) in human milk from individual women which is not readily explained by maternal factors such as smoking or illness. A potential correlate is the maternal plasma level of TGFbeta since changes in plasma concentration of TGFbeta in response to a number of pathological conditions have been well documented. The purpose of this study was to investigate the relationship between the concentration of TGFbeta1 and TGFbeta2 in a single sample of human milk and plasma obtained on the same day from 80 lactating mothers at 5 weeks postpartum. The concentration of TGFbeta1 and TGFbeta2 in the aqueous fraction of human milk ranged from 228 to 3542 pg/ml (647, 438-799; median, 25th-75th percentiles) and 98 to 13 855 pg/ml (955, 535-1999) respectively and in paired samples of plasma from 440 to 19 460 (4026, 32454656) and 92 to 1739 (620, 391-925) respectively. Thus, in milk the median ratio of TGFbeta1 to TGFbeta2 was 1:1.6 whereas the corresponding median ratio in plasma was 7:1. There was no correlation between the concentration of either isoform of TGFbeta in milk and the corresponding TGFbeta in plasma. (C) 2002 Elsevier Science Ltd. All rights reserved.