Gut biogeography of the bacterial microbiota.
Gut biogeography of the bacterial microbiota.
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DOI：
10.1038/nrmicro3552
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Mazmanian SK
中科院分区：
文献类型：
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作者：
Donaldson GP;Lee SM;Mazmanian SK
动物聚集和维持一个多样化的，但宿主特异性的肠道微生物群落。除了沿着肠道纵轴的特征性微生物组成外，在微生境中形成离散的细菌群落，如肠腔、结肠黏液层和结肠隐窝。在这篇综述中，我们研究了肠道物理生态位中共生细菌的空间分布如何影响弹性微生物生态系统的发展和维持。我们考虑了关于营养选择、免疫激活和其他机制如何控制肠道细菌生物地理的新假设，并讨论了这种空间异质性与健康和疾病的相关性。
Animals assemble and maintain a diverse, yet host-specific gut microbial community. In addition to characteristic microbial compositions along the longitudinal axis of the intestines, discrete bacterial communities form in microhabitats, such as the gut lumen, colon mucus layers and colon crypts. In this Review, we examine how spatial distribution of symbiotic bacteria among physical niches in the gut impacts the development and maintenance of a resilient microbial ecosystem. We consider novel hypotheses for how nutrient selection, immune activation and other mechanisms control the biogeography of bacteria in the gut and discuss the relevance of this spatial heterogeneity to health and disease.