Severe acute malnutrition and infection.
Severe acute malnutrition and infection.
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DOI：
10.1179/2046904714z.000000000218
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发表时间：
2014-12
影响因子：
1.8
通讯作者：
Berkley JA
中科院分区：
文献类型：
--
作者：
Jones KD;Berkley JA
严重急性营养不良 (SAM) 与常见传染病的严重程度增加有关，患有 SAM 的儿童的死亡几乎总是由感染引起。营养不良儿童与营养良好儿童的感染诊断和治疗通常不同。本简报的目的是概述支持 SAM 儿童传染病管理相关重要实际问题的证据，并强调研究差距。总体而言，本简报所涵盖的许多方面的证据基础都非常薄弱。该简报涉及抗菌药物；退烧药；结核;艾滋病病毒;疟疾;肺炎;腹泻;败血症;麻疹;尿路感染；院内感染；土壤传播的蠕虫； SAM 背景下的皮肤感染和药理学。该简介由一系列临床问题组成，我们希望这些问题能够最大限度地与当代实践相关。
Severe acute malnutrition (SAM) is associated with increased severity of common infectious diseases, and death amongst children with SAM is almost always as a result of infection. The diagnosis and management of infection are often different in malnourished versus well-nourished children. The objectives of this brief are to outline the evidence underpinning important practical questions relating to the management of infectious diseases in children with SAM and to highlight research gaps. Overall, the evidence base for many aspects covered in this brief is very poor. The brief addresses antimicrobials; antipyretics; tuberculosis; HIV; malaria; pneumonia; diarrhoea; sepsis; measles; urinary tract infection; nosocomial Infections; soil transmitted helminths; skin infections and pharmacology in the context of SAM. The brief is structured into sets of clinical questions, which we hope will maximise the relevance to contemporary practice.