Dual tumor-targeted multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined photothermal-chemotherapy.
Dual tumor-targeted multifunctional magnetic hyaluronic acid micelles for enhanced MR imaging and combined photothermal-chemotherapy.
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DOI：
10.1016/j.colsurfb.2018.02.005
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发表时间：
2018-04
期刊：
影响因子：
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通讯作者：
Shaohui Zheng;Jiwon Han;Zhen Jin;Chang-sei Kim;Sukho Park;Kyu-Pyo Kim;Jong-Oh Park;Eunpyo Choi
中科院分区：
文献类型：
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作者：
Shaohui Zheng;Jiwon Han;Zhen Jin;Chang-sei Kim;Sukho Park;Kyu-Pyo Kim;Jong-Oh Park;Eunpyo Choi
多功能聚合物胶束被开发为一种有前途的双肿瘤靶向药物递送平台，用于磁共振（MR）成像和联合光热化疗。通过肽形成过程合成HA-C16共聚物，随后将治疗剂多西紫杉醇（DTX）和超顺磁性氧化铁纳米颗粒（SPION）共封装以形成多功能胶束。胶束在水溶液中表现出均匀的纳米尺寸和显着的胶体稳定性。在测试期间观察到HA胶束的持续药物释放行为。此外，还研究了基于CD44受体介导的内吞作用的特异性靶向能力以及在外部磁场存在下增强的靶向功效。胶束内聚集的SPION在MR体模测试中表现出优异的对比效果和高r2弛豫率。此外，多功能胶束在近红外光照射下可以很容易地将光转化为热至高温，并诱导乳腺癌细胞的光热消融。所开发的多功能聚合物胶束的光热疗法与 DTX 介导的化疗相结合可以产生协同治疗效果。基于这些发现，所得的多功能胶束可能为癌症的多模式治疗诊断提供巨大潜力。
Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period. Moreover, the specific targeting capability based on CD44 recptor-mediated endocytosis and the enhanced targeting efficacy by in presence of external magnetic field were investigated. The clustered SPIONs within micelles exerted excellent contrast effect with high r2relaxivity in MR phantom test. Furthermore, the multifunctional micelles could readily convert light to heat to hyperthermia temperature upon near infrared light irradition and induce photothermal ablation to breast cancer cells. The combined photothermal therapy with DTX-mediated chemotherapy of the developed multifunctional polymeric micells could generate a synergistic therapeutic effect. Based on these findings, the resulting multifunctional micelles may provide high potential for multimodality theragnosis of cancer.