Gene therapy for obesity: progress and prospects.
Gene therapy for obesity: progress and prospects.
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发表时间：
2014-06
影响因子：
1.4
通讯作者：
Mingming Gao;Dexi Liu
中科院分区：
文献类型：
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作者：
Mingming Gao;Dexi Liu
随着对肥胖及肥胖相关疾病分子基础认识的不断深入，基因治疗已成为应对肥胖这一全球性流行病的重要手段。肥胖症的基因治疗旨在增加或减少有利于脂肪分解和能量消耗的基因产物，从而导致脂肪减少和体重减轻。它涉及治疗基因在适当细胞中的成功递送和表达。基因治疗的最终目的是恢复和维持能量稳态。在这里，我们总结了近年来在确定肥胖基因方面取得的进展，并介绍了基因治疗方法已被应用于治疗或预防肥胖的例子。讨论了基因治疗策略的优点和局限性。本综述的目的是激发进一步的研究，为成功治疗肥胖和肥胖相关疾病的新策略的发展。
Advances in understanding the molecular basis of obesity and obesity-associated diseases have made gene therapy a vital approach in coping with this world-wide epidemic. Gene therapy for obesity aims to increase or decrease gene product in favor of lipolysis and energy expenditure, leading toward fat reduction and loss of body weight. It involves successful delivery and expression of therapeutic genes in appropriate cells. The ultimate goal of gene therapy is to restore and maintain energy homeostasis. Here we summarize progress made in recent years in identifying genes responsible for obesity and present examples where the gene therapy approach has been applied to treating or preventing obesity. Discussion on advantages and limitations of gene therapy strategies employed is provided. The intent of this review is to inspire further studies toward the development of new strategies for successful treatment of obesity and obesity-associated diseases.