Age and gender influence basal and stress-modulated hypothalamic-pituitary-thyroidal function in Fischer 344/N rats
Age and gender influence basal and stress-modulated hypothalamic-pituitary-thyroidal function in Fischer 344/N rats
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DOI：
10.1159/000127150
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发表时间：
1996-12-01
影响因子：
4.1
通讯作者：
Chrousos, GP
中科院分区：
文献类型：
--
作者：
Cizza, G;Brady, LS;Chrousos, GP
为了研究基线和应激时下丘脑-垂体-甲状腺（HPT）轴可能的性别和年龄相关变化，我们研究了健康幼（3个月）和大（23个月）雌性344/N Fischer大鼠在基础状态和固定（IMMO） 2小时后，与年龄匹配的雄性大鼠平行。在基线时，年轻雌性和雄性动物之间的HPT轴功能没有重大差异。老年与男性和女性的中枢甲状腺功能受损有关，尽管女性的程度远低于男性。血浆催乳素（PRL）水平在年轻女性和男性中相似，但在老年女性中高于男性。IMMO对雌雄动物的HPT轴功能均有抑制作用，但对老年动物无抑制作用。因此，IMMO降低了年轻大鼠的血浆TSH和下丘脑TRH mRNA水平，但在老年大鼠中没有。IMMO增加了年轻和老年男性的血浆PRL，但对年轻和老年女性没有任何影响。总之，这些数据表明，年龄和性别对HPT轴在基线和应激后的功能有不同的影响。
To investigate possible gender- and age-associated changes of the hypothalamic-pituitary-thyroid (HPT) axis at baseline and during stress, we studied healthy young (3-month) and old (23-month) female 344/N Fischer rats at the basal state and after 2 h of immobilization (IMMO), in parallel to age-matched male rats. At baseline, there were no major differences of HPT axis functions between young female and male animals. Old age was associated with impaired central thyroid function in both genders, albeit to a much lesser extent in females than in males. Plasma prolactin (PRL) levels were similar in young females and males but were higher in old females than males. IMMO inhibited HPT axis functions in both genders in young, but not old animals. Thus, plasma TSH and hypothalamic TRH mRNA levels were decreased by IMMO in young, but not in old rats of both genders. IMMO increased plasma PRL in young and old males, but did not have any effect in young and old females. In summary, these data indicate that age and gender exert diverse effects on HPT axis functions at baseline and after stress.