Heme/copper assembly mediated nitrite and nitric oxide interconversion.
Heme/copper assembly mediated nitrite and nitric oxide interconversion.
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DOI：
10.1021/ja3083818
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发表时间：
2012-11-21
影响因子：
15
通讯作者：
Karlin, Kenneth D.
中科院分区：
文献类型：
--
作者：
Hematian, Shabnam;Siegler, Maxime A.;Karlin, Kenneth D.
The hemea3/CuB active site of cytochrome c oxidase is responsible for cellular nitrite reduction to nitric oxide; the same center can return NO to the nitrite pool via oxidative chemistry. Here, we show that a partially reduced heme/Cu assembly reduces NO2− ion producing nitric oxide. The heme serves as the reductant while the CuII ion is also required. In turn, a µ-oxo hemeFeIII-O-CuII complex facilitates NO oxidation to nitrite; the final products are the reduced heme and CuII-nitrite complexes.
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