PERINATAL SALT INTAKE ALTERS BLOOD-PRESSURE AND SALT BALANCE IN HYPERTENSIVE RATS
PERINATAL SALT INTAKE ALTERS BLOOD-PRESSURE AND SALT BALANCE IN HYPERTENSIVE RATS
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DOI：
10.1161/01.hyp.15.2.177
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发表时间：
1990-02-01
期刊：
影响因子：
8.3
通讯作者：
MORGAN, TO
中科院分区：
文献类型：
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作者：
DINICOLANTONIO, R;HOY, K;MORGAN, TO
在子宫内和哺乳期暴露于高盐（3% NaCl, wt/wt）、低盐（0.1%）、对照盐（0.8%）或高钾（2.2% KCl, wt/wt）[修正]母性饮食后，对冈本品系自发性高血压大鼠的血压和口服盐负荷排泄率进行了检测。断奶后，饲喂含0.8% NaCl的日粮。在60周的观察中，子代组之间的生长速度有微小但显著的差异，围产期低盐和高盐饮食的大鼠比对照组或高钾饮食的大鼠体重轻。在8周龄时，所有饮食组的体重和血压之间存在显著的正相关，但在16和24周龄时则没有。暴露于围产期低盐饮食的大鼠的血压明显低于血压相似的其他三组。与其他三个饮食组相比，低盐大鼠在单次口服盐负荷（0.15 M盐水，体重1%）后也表现出夸大的尿钠，这三个饮食组之间没有什么不同。与其他三组相比，高钾大鼠在盐负荷后的钾尿和利尿均有所减少。在60周龄时，与其他组相比，围产期低盐饮食组的大鼠肾上腺明显变重，高钾饮食组的血浆肾素浓度显著升高。因此，围产期母体电解质摄入可能改变遗传易感个体成熟时的体液稳态。
Blood pressure and the rate of excretion of an oral salt load were examined in spontaneously hypertensive rats of the Okamoto strain after exposure in utero and during suckling to a high salt (3% NaCl, wt/wt), low salt (0.1%), control salt (0.8%), or high potassium (2.2% KCl, wt/wt) [corrected] maternal diet. After weaning, all offspring were given a diet containing 0.8% NaCl. There were small but significant differences in growth rate among offspring groups over the 60 weeks of observation, with rats exposed to perinatal low salt and high salt diet being lighter than those given control or high potassium diet. There were positive, significant correlations between body weight and blood pressure in all dietary groups at 8 weeks of age but not 16 or 24 weeks. Rats exposed to perinatal low salt diet had significantly lower blood pressures than the other three groups, which had similar blood pressures. Low salt rats also exhibited an exaggerated natriuresis after a single, oral salt load (0.15 M saline, 1% body weight) compared with the other three diet groups, which were not different from each other. High potassium rats had a reduced kaliuresis and diuresis after the salt load when compared with the other three groups. At 60 weeks of age, rats that received perinatal low salt diet had significantly heavier adrenal glands when compared with the other groups, and the high potassium group had significantly elevated plasma renin concentrations. Thus, maternal electrolyte intake during the perinatal phase may alter body fluid homeostasis in genetically susceptible individuals at maturity.