Effect of smoking cessation on major histologic types of lung cancer
Effect of smoking cessation on major histologic types of lung cancer
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DOI：
10.1378/chest.120.5.1577
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发表时间：
2001-11-01
期刊：
影响因子：
9.6
通讯作者：
Mutgi, AB
中科院分区：
文献类型：
--
作者：
Khuder, SA;Mutgi, AB
研究目标：众所周知，戒烟后患肺癌的风险会下降。然而，不同组织学类型肺癌的下降程度尚不清楚。我们对同行评审的研究进行了荟萃分析，以评估戒烟对主要组织学类型肺癌发生率的影响。 设计：通过计算机数据库（即 MEDLINE 和 CANCERLIT）的搜索来确定 1970 年至 1999 年间以英文发表的研究。使用固定和随机效应模型计算了 27 项研究的相对风险和 95% 置信区间的综合估计。对男性和女性进行了单独的分析。结果：戒烟与所有主要组织学类型肺癌风险的降低相关。减少最多的是小细胞肺癌（SCLC）和鳞状细胞癌（SQC），减少最少的是大细胞癌和腺癌。在女性中，SQC 和 SCLC 的综合风险高于男性。女性吸烟强度的剂量反应曲线更陡。结论：本研究的结果表明，戒烟可最大程度地降低 SCLC 和 SQC。这种影响在重度吸烟者中最为明显，尤其是女性。
Study objectives: It is well-recognized that the risk of lung cancer declines after smoking cessation. However, the degree of decline in different histologic types of lung cancer is not well understood. We conducted a meta-analysis of peer-reviewed studies to assess the effect of smoking cessation on rates of major histologic types of lung cancer.Design: Studies published in English between 1970 and 1999 were identified through searches of computerized databases (ie, MEDLINE and CANCERLIT). Combined estimates of relative risk and 95% confidence intervals were calculated for 27 studies using fixed and random effects models. Separate analyses were conducted for men and women.Results: Smoking cessation was associated with a reduction in the risk of all the major histologic types of lung cancer. The highest reduction was in small cell lung carcinoma (SCLC) and squamous cell carcinoma (SQC), and the lowest reduction was seen in large cell cancer and adenocarcinoma. In women, the combined risks for SQC and SCLC were higher than those in men. The dose-response curve for intensity of smoking was steeper in women.Conclusion: The findings of this study suggest that smoking cessation results in the greatest reductions for SCLC and SQC. This effect is most marked in heavy smokers, particularly among women.