cis-regulatory control circuits in development
cis-regulatory control circuits in development
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DOI：
10.1016/j.ydbio.2004.03.031
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发表时间：
2004-07-01
影响因子：
2.7
通讯作者：
Davidson, EH
中科院分区：
文献类型：
--
作者：
Howard, ML;Davidson, EH
在发育过程中，一个生物体要经历多轮模式形成，随着每一轮后续的细胞分裂和特化，产生越来越高的复杂性。执行这一过程的指令被编码在顺式调控模块中，这些模块指导发育转录因子和信号分子的表达。顺式调控模块内的每个转录因子结合位点都提供了有关基因何时、何地以及在多大程度上被激活的信息，通过剖析驱动某一给定基因的模块，可以准确地确定控制该基因表达的所有输入因素。此外，通过将每个基因的输出映射到其他基因的输入，就有可能对发育回路甚至整个网络进行逆向工程。在这种更高层次的组织水平上，出现了用于确定祖细胞区域、锁定调控状态以及推动发育向前的常见两侧对称动物策略。（C）2004爱思唯尔公司。保留所有权利。
During development, an organism undergoes many rounds of pattern formation, generating ever-greater complexity with each ensuing round of cell division and specification. The instructions for executing this process are encoded. in the cis-regulatory modules that direct the expression of developmental transcription factors and signaling molecules. Each transcription factor binding site within a cis-regulatory module contributes information about when, where, or how much a gene is turned on, and by dissecting the modules driving a given gene, all the inputs governing expression of the gene can be accurately identified. Furthermore, by mapping the output of each gene to the inputs of other genes, it is possible to reverse engineer developmental circuits and even whole networks. At this higher level of organization, common bilaterian strategies for specifying progenitor fields, locking down regulatory states, and driving development forward emerge. (C) 2004 Elsevier Inc. All rights reserved.