Handedness in twins: Joint analysis of data from 35 samples
Handedness in twins: Joint analysis of data from 35 samples
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DOI：
10.1375/twin.9.1.46
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发表时间：
2006-02-01
影响因子：
0.9
通讯作者：
Martin, NG
中科院分区：
文献类型：
--
作者：
Medland, SE;Duffy, DL;Martin, NG
同时分析35个双胞胎样本的利手数据（合并样本量为21，127对双胞胎）发现一个小但显著的加性遗传效应，占方差的25.47%（95%置信区间[CI] 15.69-29.51%）。未检测到常见的环境影响（C = 0.00; 95% CI 0.00-7.67%），大部分方差（74.53%）由个体特有的因素解释（95% CI 70.49-78.67%）。在使用类似方法评估利手的研究中或使用不同方法的研究中未观察到显著异质性。在个体水平上，大多数研究没有足够的力量拒绝一个纯粹独特的环境模型，因为没有足够的力量来检测家族聚集。这种力量的缺乏在研究中很少被提及，并导致了一种误解，即双胞胎的利手研究没有信息。
Simultaneous analysis of handedness data from 35 samples of twins (with a combined sample size of 21,127 twin pairs) found a small but significant additive genetic effect accounting for 25.47% of the variance (95% confidence interval [CI] 15.69-29.51%). No common environmental influences were detected (C = 0.00; 95% Cl 0.00-7.67%), with the majority of the variance, 74.53%, explained by factors unique to the individual (95% Cl 70.49-78.67%). No significant heterogeneity was observed within studies that used similar methods to assess handedness, or across studies that used different methods. At an individual level the majority of studies had insufficient power to reject a purely unique environmental model due to insufficient power to detect familial aggregation. This lack of power is seldom mentioned within studies, and has contributed to the misconception that twin studies of handedness are not informative.