Multiple bronchiolar adenomas with malignant transformation and CCNE1 mutation: a case report and literature review.
Multiple bronchiolar adenomas with malignant transformation and CCNE1 mutation: a case report and literature review.
复制标题
DOI：
10.1186/s13019-021-01687-5
复制
发表时间：
2021-10-18
影响因子：
1.6
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Li X;Wu Y;Hui D;Luo X;Wu W;Zhang J;Chen H
Bronchiolar adenoma (BA) is a recently proposed diagnostic terminology, which is considered as the expansion of the concept of ciliated muconodular papillary tumors. BA is considered to be a benign neoplasm, but a few previous cases have been reported with the possibility of malignant transformation. Therefore, the genetic and histological nature of BA is controversial so far. We describe a rare case of multiple BAs with malignant transformation and CCNE1 (cyclin E1) mutation to increase the understanding of this disease. A 56-year-old woman was admitted to our hospital due to two ground-glass nodules (GGNs) in the left lung detected by chest CT without symptom. The pure GGN located in the upper lingual segment about 6 mm in diameter and another mixed GGN located in the dorsal segment about 7 mm. The two GGNs have been found a year ago without treatment, and the mixed GGN become larger to 8 mm with vacuole sign in the next year health checkup. We performed a wedge resection of the two nodules completely by video-assisted thoracoscopy (VATS). Postoperative pathology indicated that the pure GGN was atypical bronchial adenoma, while the mixed GGN was atypical bronchial adenoma with malignant transformation which was missed in frozen section. Gene mutations analysis by next-generation sequencing (NGS) showed CCNE1 gene mutation in both lesions, and her-2 mutation was identified in the mixed GGN. The programmed cell death 1 ligand 1 (PD-L1) expression analysis of tumor cells showed 0% and less than 1% in the pure GGN and the mixed GGN, respectively. BA is generally considered to be a benign tumor. The present study indicated that BA may be carcinogenic in atypical cases with some driver genes mutation and we should be vigilant for its potentiality of malignant transformation in clinical practice.
登录
查看更多内容
影响因子：
4.8
作者：
Liang, Yuan;Rong, Xuezhu;Wang, Enhua
通讯作者：
Wang, Enhua
DOI：
10.1097/pas.0000000000001086
发表时间：
2018-08
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Chang JC;Montecalvo J;Borsu L;Lu S;Larsen BT;Wallace WD;Sae-Ow W;Mackinnon AC;Kim HR;Bowman A;Sauter JL;Arcila ME;Ladanyi M;Travis WD;Rekhtman N
通讯作者：
Rekhtman N
DOI：
10.3760/cma.j.cn112151-20190821-00459
发表时间：
2020-06-08
期刊：
Zhonghua bing li xue za zhi = Chinese journal of pathology
影响因子：
--
作者：
Zhang, J;Shao, J C;Teng, H H
通讯作者：
Teng, H H
影响因子：
3.7
作者：
Zhang, Yinbin;Shan, Changyou;Zhang, Shuqun
通讯作者：
Zhang, Shuqun
影响因子：
11.5
作者：
Etemadmoghadam, Dariush;Au-Yeung, George;Bowtell, David D.
通讯作者：
Bowtell, David D.