Collagen XV: exploring its structure and role within the tumor microenvironment.
Collagen XV: exploring its structure and role within the tumor microenvironment.
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DOI：
10.1158/1541-7786.mcr-12-0662
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Harris A
中科院分区：
文献类型：
--
作者：
Clementz AG;Harris A
The extracellular matrix (ECM) is a critical component of stroma-to-cell interactions that subsequently activate intracellular signaling cascades, many of which are associated with tumor invasion and metastasis. It contains a wide range of proteins with multiple functions including cytokines, cleaved cell-surface receptors, secreted epithelial cell proteins, and structural scaffolding. Fibrillar collagens are abundant in the normal ECM where they surround cellular structures and provide structural integrity. However during the initial stages of invasive cancers, the ECM is among the first places to be compromised. Also present in the normal ECM is the non-fibrillar collagen XV, which is seen in the basement membrane (BM) zone but is lost prior to tumor metastasis in several organs. In contrast, the tumor microenvironment often exhibits increased synthesis of the fibrillar collagens I and IV, which are associated with fibrosis. The unique localization of collagen XV and its disappearance prior to tumor invasion suggest a role in maintaining BM integrity and preventing the migration of tumor cells across this barrier. Here we examine the structure of collagen XV, its functional domains, and its involvement in cell-surface receptor-mediated signaling pathways, which provide further insights into its role in the suppression of malignancy.
