Explaining the relation between education and postmenopausal breast cancer
Explaining the relation between education and postmenopausal breast cancer
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DOI：
10.1093/oxfordjournals.aje.a009114
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发表时间：
1997-02-15
影响因子：
5
通讯作者：
Pamuk, ER
中科院分区：
文献类型：
--
作者：
Heck, KE;Pamuk, ER
作者使用国家健康和营养调查I流行病学随访研究的数据，研究了由教育水平定义的社会经济地位与绝经后乳腺癌发病率之间的关系。这项研究的女性参与者从1971-1974年到1992-1993年进行了跟踪调查。考克斯比例风险模型被用来确定乳腺癌发病率与教育水平之间的关系。教育水平与绝经后乳腺癌风险之间存在直接的剂量反应关系。一些乳腺癌的风险因素，包括身高和生育相关的风险，如未经产，被发现调解这种关系。这些因素的调整减少，但没有消除，教育水平和绝经后乳腺癌的风险之间的正相关关系，然而，该协会不再具有统计学意义，高等教育和乳腺癌风险增加之间的关联似乎在很大程度上解释了已知的乳腺癌风险因素的差异。
The authors examined the relation between socioeconomic status, as defined by education level, and postmenopausal breast cancer incidence using data from the National Health and Nutrition Examination Survey I Epidemiologic Followup Study. Female participants in the study were followed from 1971-1974 to 1992-1993. Cox proportional hazards modeling was used to determine the relation between breast cancer incidence and education level. There was a direct dose-response association between education level and postmenopausal breast cancer risk. Several breast cancer risk factors, including height and reproductive-related risks such as nulliparity, were found to mediate this relation. Adjustment for these factors reduced, but did not eliminate, the positive relation between education level and risk of postmenopausal breast cancer; however, the association was no longer statistically significant, The association between higher education and increased risk of breast cancer appears to be largely explained by differences in the known risk factors for breast cancer.