Small macrophages are present in early childhood respiratory disease
Small macrophages are present in early childhood respiratory disease
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DOI：
10.1016/j.jcf.2011.11.008
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发表时间：
2012-05-01
影响因子：
5.2
通讯作者：
Sly, Peter D.
中科院分区：
文献类型：
--
作者：
Garratt, Luke W.;Wright, Adam K. A.;Sly, Peter D.
背景：最近，在CF和COPD患者的痰中观察到了一种确定的“小巨噬细胞”表型。然而，很少有人知道这种表型的患病率在气道的幼儿。由于呼吸道炎症开始在CF早期，我们假设，这些小的巨噬细胞将增加在儿科CF支气管肺泡灌洗（BAL）。方法：在CF和疾病对照BAL中的巨噬细胞群体进行了评估多色流式细胞术。结果：CF中存在小巨噬细胞（n=35，平均36 +/- 12%的BAL巨噬细胞），但与呼吸系统疾病对照组（n=7，平均40 +/- 21%）无显著差异。小巨噬细胞数量与BAL中性粒细胞数量显著相关（r=0.44，p
Background: Recently, an established "small macrophage" phenotype has been observed in the sputum of patients with CF and COPD. However, little is known about the prevalence of this phenotype in the airways of young children. Since respiratory inflammation begins early in CF, we hypothesised that these small macrophages would be increased in paediatric CF bronchoalveolar lavage (BAL).Methods: Macrophage populations in CF and disease control BAL were assessed by multicolour flow cytometry. BAL inflammatory indices were collected as part of the AREST-CF programme.Results: Small macrophages were present in CF (n=35, mean 36 +/- 12% of BAL macrophages) but not significantly different to the respiratory disease controls (n=7, mean 40 +/- 21%). Number of small macrophages correlated significantly with number of BAL neutrophils (r=0.44, p