The role of TT virus infection in acute viral hepatitis
The role of TT virus infection in acute viral hepatitis
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DOI：
10.1002/hep.510290613
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发表时间：
1999-06-01
期刊：
影响因子：
13.5
通讯作者：
Saisho, H
中科院分区：
文献类型：
--
作者：
Kanda, T;Yokosuka, O;Saisho, H
近年来，输血传播病毒（transfusion-transmitted virus，TTV）被发现是非甲-戊型肝炎的潜在病原体。TTV与各型急性病毒性肝炎临床病程的关系尚不清楚。对1984 ~ 1998年间在千叶大学附属医院住院的125例急性病毒性肝炎患者和100例肝功能正常者进行血清TTV检测。用聚合酶链反应（PCR）检测血清TTV DNA和基因型。35例非甲-戊型肝炎患者中TTVDNA阳性率为43%（15/35），33例丙型肝炎患者中TTVDNA阳性率为42%（14/33），28例甲型肝炎患者中TTVDNA阳性率为29%（8/28），29例B型肝炎患者中TTVDNA阳性率为24%（7/29），100例肝功能正常者中TTVDNA阳性率为37%（37/100）。非甲-戊型肝炎与甲型、B、丙型肝炎或对照组之间的检出率无统计学差异。TTV基因型在非A-E型、A型、B型、C型和对照组中的分布相似。在非甲-戊型、甲型、B型或丙型肝炎患者中，有或无TTV的急性疾病的临床特征相似。虽然TTV常在非甲-戊型急性肝炎中检出，但TTV的病因学作用尚不明确。
Recently, transfusion-transmitted virus (TTV) was discovered to be a potential causative agent for non-A-E hepatitis. Little is known about the relation between TTV and the clinical courses of various types of acute viral hepatitis. One hundred twenty-five patients with acute viral hepatitis who were admitted to the Chiba University Hospital between 1984 and 1998 and 100 persons with normal liver function tests were tested for the presence of TTV in their sera. Serum samples were tested for TTV DNA and genotype by polymerase chain reaction (PCR). TTV DNA was detected in 15 of 35 patients (43%) with non-A-E hepatitis, 14 of 33 patients (42%) with hepatitis C, 8 of 28 patients (29%) with hepatitis A, 7 of 29 patients (24%) with hepatitis B, and 37 of 100 subjects with normal liver function tests (37%). The detection rate did not differ statistically between non-A-E hepatitis and hepatitis A, B, C, or controls. The distribution of TTV genotypes was similar in non-A-E, A, B, C types, and controls. The clinical characteristics of the acute illnesses were similar for patients with or without TTV in hepatitis non-A-E, A, B, or C. Although TTV was detected frequently in non-A-E acute hepatitis, no etiologic role for TTV could be established.