Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection
Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection
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DOI：
10.1128/jvi.01466-10
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发表时间：
2010-11-01
影响因子：
5.4
通讯作者：
Douek, Daniel C.
中科院分区：
文献类型：
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作者：
Murray, Shannon M.;Down, Carrie M.;Douek, Daniel C.
活化T细胞水平的增加是人类免疫缺陷病毒（HIV）感染慢性阶段的标志，并且与HIV疾病进展高度相关。我们评估了氯喹（CQ）作为一种潜在的治疗，以减少免疫激活在艾滋病毒感染。我们发现，CQ治疗期间，CD 38（+）HLA-DR+ CD 8 T细胞的频率以及CD 8和CD 4 T细胞中Ki-67的表达显著降低。我们的数据表明，CQ治疗可降低系统性T细胞免疫激活，因此，它的使用可能对某些HIV感染者群体有益。
Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR+ CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.