Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students.
Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students.
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DOI：
10.1177/1740774516643265
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
Abella BS
中科院分区：
文献类型：
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作者：
Blewer AL;Li J;Ikeda DJ;Leary M;Buckler DG;Riegel B;Desai S;Groeneveld PW;Putt ME;Abella BS
招募受试者对于任何临床试验的成功都至关重要，但实现这一目标可能是一项具有挑战性的奋进。志愿护士和学生招募者是潜在的一个重要来源，招募医院为基础的试验，然而，很少有人知道这些类型的招募者的疗效或成本。我们评估了志愿临床护士和健康科学专业的学生在一项以医院为基础的、务实的心肺复苏教育临床试验中招募家庭成员的比率，以及他们实现目标招募目标的能力。我们假设，学生将有更高的入学率，更符合成本效益相比，护士。从8个机构招募了志愿护士和注册学生。参与的护士主要是床边护士或护士教育工作者，而学生是当地大学的医学预科，护理预科和健康预科学生。我们记录了每个入组者招募入临床试验的频率。采用混合方法调查评估了入学者对招聘的印象。根据入组数据估计成本。使用描述性统计和广义估计方程分析总体入组数据。从2012年2月至2014年11月，260名医院工作人员（167名护士和93名学生）招募了1，493名心脏病患者家属，实现了预定的招募目标。其中822人（55%）是护士，671人（45%）是学生。总体而言，学生每月比护士多招收5.44（95% CI：2.88，10.27）名受试者（p<0.01）。同意参加招募后，学生至少招募一名家庭成员的机会增加了2.85（95% CI 1.09，7.43）（p=0.03）。在至少招募一名受试者的人群中，护士平均每月招募0.51名受试者（95%CI：0.42，0.59），而学生平均每月招募1.63名受试者（95%CI：1.37，1.90）（p<0.01）。在198名接受调查的医院工作人员（127名护士，71名学生）中，168/198（85%）对进行招生感到有信心。每名注册者的可变成本为护士每科25.38美元，学生每科23.30美元。总的来说，志愿者学生每月以低于护士的费用注册更多的科目。这项工作表明，一个务实的临床试验的招聘目标，可以成功地获得使用护士和学生。
Recruitment of subjects is critical to the success of any clinical trial, but achieving this goal can be a challenging endeavor. Volunteer nurse and student enrollers are potentially an important source of recruiters for hospital-based trials; however, little is known of either the efficacy or cost of these types of enrollers. We assessed volunteer clinical nurses and health science students in their rates of enrolling family members in a hospital-based, pragmatic clinical trial of cardiopulmonary resuscitation education, and their ability to achieve target recruitment goals. We hypothesized that students would have a higher enrollment rate and are more cost-effective compared to nurses. Volunteer nurses and student enrollers were recruited from eight institutions. Participating nurses were primarily bedside nurses or nurse educators while students were pre-medical, pre-nursing, and pre-health students at local universities. We recorded the frequency of enrollees recruited into the clinical trial by each enroller. Enrollers’ impressions of recruitment were assessed using mixed methods surveys. Cost was estimated based on enrollment data. Overall enrollment data were analyzed using descriptive statistics and generalized estimating equations. From 02/2012 to 11/2014, 260 hospital personnel (167 nurses and 93 students) enrolled 1,493 cardiac patients’ family members, achieving target recruitment goals. Of those recruited, 822 (55%) were by nurses, while 671 (45%) were by students. Overall, students enrolled 5.44 (95% CI: 2.88, 10.27) more subjects per month than nurses (p<0.01). After consenting to participate in recruitment, students had a 2.85 (95% CI 1.09, 7.43) increased chance of enrolling at least one family member (p=0.03). Among those who enrolled at least one subject, nurses enrolled a mean of 0.51(95% CI 0.42, 0.59) subjects monthly, while students enrolled 1.63 (95%CI: 1.37, 1.90) per month (p<0.01). Of 198 surveyed hospital personnel (127 nurses, 71 students), 168/198 (85%) felt confident conducting enrollment. The variable cost per enrollee recruited was $25.38 per subject for nurses and $23.30 per subject for students. Overall, volunteer students enrolled more subjects per month at a lower cost than nurses. This work suggests that recruitment goals for a pragmatic clinical trial can be successfully obtained using both nurses and students.