Differential association between two human MHC class I antigens and an adenoviral glycoprotein.
Differential association between two human MHC class I antigens and an adenoviral glycoprotein.
复制标题
两种人类 MHC I 类抗原和腺病毒糖蛋白之间的差异关联。
DOI：
10.4049/jimmunol.137.3.1003
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发表时间：
1986
影响因子：
4.4
通讯作者：
P. A. Peterson
中科院分区：
文献类型：
--
作者：
L. Severinsson;I. Martens;P. A. Peterson
The glycoprotein E19, encoded in early region 3 of adenovirus-2, forms complexes with major histocompatibility complex class I antigens. As a result of the complex formation, the intracellular transport of the class I antigens is abrogated, and adenovirus-infected cells display gradually diminishing quantities of cell surface-expressed class I molecules. To assess whether the E19 protein interacts equally well with different class I antigens, the associations between the viral protein and HLA-A2 and HLA-B7 antigens have been estimated. By infecting transfected HeLa cells expressing various amounts of HLA-A2 and HLA-B7 molecules, respectively, with various infectious doses of adenovirus-2, experimental conditions could be established that allowed quantitative estimates of the interactions to be determined. It was found that HLA-A2 molecules and the E19 protein interacts with a binding constant that is more than twice as high as that for HLA-B7 antigens and the viral protein. It is suggested that the pathogenicity of the virus may be dependent on the HLA-type of the infected individual.
