Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria
Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria
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DOI：
10.1016/j.diabres.2011.01.008
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发表时间：
2011-05-01
影响因子：
5.1
通讯作者：
Maegawa, Hiroshi
中科院分区：
文献类型：
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作者：
Miyazawa, Itsuko;Araki, Shin-ichi;Maegawa, Hiroshi
目的：我们的研究的目的是探讨是否可溶性肿瘤坏死因子α受体（sTNFR）1和2的血清水平是2型糖尿病患者肾功能不全的标志物没有明显的蛋白尿方法：日本2型糖尿病患者没有明显的蛋白尿（n = 168）在2001年的前瞻性观察随访研究纳入回顾性分析。在基线时，采用夹心ELISA法测定血清sTNFR 1和sTNFR 2水平。结果：sTNFR 1和sTNFR 2水平密切相关。基线时，sTNFR 1和sTNFR 2与eGFR呈负相关。5年后，sTNFR 1和sTNFR 2均高水平的患者显示eGFR下降幅度更大（-13.8 +/- 15.5% vs-8.5 +/-11.8%，P = 0.027），GFR下降≥ 25%的风险比仅一种受体高水平或两种受体均低水平的患者高4倍。这些协会在糖尿病women.Conclusions：sTNFR 1和sTNFR 2的水平较高的2型糖尿病患者无蛋白尿，特别是糖尿病妇女与eGFR下降更大。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Aim: The aim of our study was to investigate whether serum levels of soluble tumor necrosis factor alpha receptor (sTNFR) 1 and 2 are markers for renal dysfunction in type 2 diabetic patients without overt proteinuria.Methods: Japanese type 2 diabetic patients without overt proteinuria (n = 168) enrolled in the prospective observational follow-up study in 2001 were retrospectively analyzed. At baseline, the serum levels of sTNFR1 and sTNFR2 were measured by sandwich ELISA. The associations between these markers and change in estimated glomerular filtration rate (eGFR) after 5 years were evaluated.Results: The levels of sTNFR1 and sTNFR2 closely correlated. At baseline, sTNFR1 and sTNFR2 associated inversely with eGFR. After 5 years, patients with high level of both sTNFR1 and sTNFR2 showed a greater decline in eGFR (-13.8 +/- 15.5% versus -8.5 +/- 11.8%, P = 0.027) and a 4-fold higher risk for a GFR decline of >= 25% than those with high level of only one receptor or low level of both receptors. These associations were enhanced in diabetic women.Conclusions: The higher levels of sTNFR1 and sTNFR2 were associated with a greater decline in eGFR in type 2 diabetic patients without proteinuria, especially in diabetic women. (C) 2011 Elsevier Ireland Ltd. All rights reserved.