Effects of the prostaglandin synthetase inhibitor indomethacin on tumorigenesis, tumor proliferation, cell kinetics, and receptor contents of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague-Dawley rats fed a high- or low-fat diet.
Effects of the prostaglandin synthetase inhibitor indomethacin on tumorigenesis, tumor proliferation, cell kinetics, and receptor contents of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague-Dawley rats fed a high- or low-fat diet.
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发表时间：
1991-05
期刊：
影响因子：
11.2
通讯作者：
Masakuni Noguchi;T. Taniya;N. Koyasaki;T. Kumaki;Itsuo Miyazaki;Yuji Mizukami
中科院分区：
文献类型：
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作者：
Masakuni Noguchi;T. Taniya;N. Koyasaki;T. Kumaki;Itsuo Miyazaki;Yuji Mizukami
已经在雌性 Sprague-Dawley 大鼠中检查了吲哚美辛对肿瘤发生、肿瘤增殖、细胞动力学和 7,12-二甲基苯并（a）蒽诱导的乳腺癌受体含量的影响。在单剂量 5 mg 7,12-二甲基苯并（a）蒽灌胃后 7 天开始，给大鼠喂食高脂肪（20% 玉米油）或低脂肪（0.5% 玉米油）饮食，含或不含 0.005% 吲哚美辛。结果表明，吲哚美辛完全阻断了脂肪对肿瘤发生的刺激作用，表现为肿瘤发生率降低、每组肿瘤数量减少以及潜伏期增加。然而，与预期相反，吲哚美辛在高脂饮食组和低脂饮食组中均促进肿瘤增殖，肿瘤大小增加、溴脱氧尿苷标记指数增加和潜在肿瘤倍增时间缩短证明了这一点。肿瘤的雌激素受体或孕激素受体含量没有显着差异。因此可以得出结论，吲哚美辛显着减少高脂肪饮食组的肿瘤发生，但显着促进高脂肪饮食组和低脂肪饮食组的肿瘤增殖。
The effects of indomethacin on tumorigenesis, tumor proliferation, cell kinetics, and receptor content of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma have been examined in female Sprague-Dawley rats. The rats were fed either a high-fat (20% corn oil) or low-fat (0.5% corn oil) diet with or without 0.005% indomethacin starting 7 days after intragastric administration of a single dose of 5 mg 7,12-dimethylbenz(a)anthracene. The results demonstrated that indomethacin completely blocked the stimulatory effect of fat on tumorigenesis, as demonstrated by a decreased tumor incidence, a decreased number of tumors per group, and an increased latency. Contrary to what had been expected, however, indomethacin promoted tumor proliferation in both the high- and low-fat diet groups, as evidenced by an increased tumor size, an increased bromodeoxyuridine-labeling index, and a decreased potential tumor-doubling time. No significant difference in either the estrogen receptor or progesterone receptor content of the tumor was noted. It can be concluded, therefore, that indomethacin significantly reduced tumorigenesis in the high-fat diet group but significantly promoted tumor proliferation in both the high- and low-fat diet groups.