All Glioblastoma Are Not Equal: Distinct Spatial Immune Profiles Between De Novo and Recurrent Tumors.

All Glioblastoma Are Not Equal: Distinct Spatial Immune Profiles Between De Novo and Recurrent Tumors.
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所有胶质母细胞瘤都不相同:新发肿瘤和复发肿瘤之间不同的空间免疫特征。

DOI:
10.1158/2326-6066.cir-22-0400
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发表时间:
2022
影响因子:
10.1
通讯作者:
Lathia,JustinD
Lathia,JustinD
中科院分区:
医学1区
文献类型:
--
作者:
Bayik,Defne;Lee,Juyeun;Lathia,JustinD

文献摘要

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缺乏对胶质母细胞瘤(GBM)免疫抑制微环境的了解阻碍了免疫治疗的成功应用。在这个问题上,Alanio及其同事确定了复发性和新发GBM之间不同的T细胞定位特征,强调了空间异质性的重要性,并提供了探索改善GBM结果的新途径。第800页(3)。
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