Effect of inter-swallow interval on striated esophagus peristalsis; a comparative study with smooth muscle esophagus.
Effect of inter-swallow interval on striated esophagus peristalsis; a comparative study with smooth muscle esophagus.
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吞咽间隔对横纹食管蠕动的影响
DOI：
10.1111/nmo.14608
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发表时间：
2023
影响因子：
3.5
通讯作者：
Shaker,Reza
中科院分区：
文献类型：
--
作者：
Edeani,Francis;Sanvanson,Patrick;Mei,Ling;Agrawal,Dilpesh;Kern,Mark;Kovacic,Katja;Shaker,Reza
背景吞咽间期对食道平滑肌收缩的影响是有文献记载的。然而，对横纹食道蠕动的影响还没有系统的研究。更好地了解健康和疾病中横纹食道的运动功能可能会加强对测压研究的解释，并为临床护理提供信息。本研究的目的是通过对20名健康受试者和28名受试者进行两组研究：(1)测定不同吞咽间隔对健康受试者的影响；(2)评价吸管促进超短吞咽间隔的影响。与平滑食道不同，S的吞咽间隔在30~5 的范围内，横纹食道收缩积分没有显著变化。相反，在吸管促进的多次快速吞咽过程中，超短间隔(<；2 S)导致横纹食道的蠕动缺失或减少。结论和推断，在超短间隔吞咽时，横纹食道的蠕动受到压力观测的抑制。短至5 的吞咽间隔抑制食道平滑肌蠕动的S不抑制横纹肌的蠕动。这些观察的机制尚不清楚，但可能与中枢或肌间神经系统的影响或咽部生物力学的影响有关。
BackgroundEffect of inter‐swallow interval on the contractility of smooth muscle esophagus is well‐documented. However, the effects on peristalsis of the striated esophagus have not been systematically studied. A better understanding of striated esophagus motor function in health and disease may enhance the interpretation of manometric studies and inform clinical care. The aim of this study was to assess the effect of inter‐swallow interval on striated esophagus compared to findings with that of the smooth muscle esophagus.MethodsWe performed two sets of studies to (1) determine the effect of various inter‐swallow interval in 20 healthy volunteers and (2) assess the effect of ultra‐short swallow intervals facilitated by straw drinking in 28 volunteers. We analyzed variables using ANOVA with Tukey's pairwise comparison and paired t‐test.Key resultsUnlike smooth muscle esophagus, the striated esophagus contractile integral did not change significantly for swallow intervals ranging from 30 to 5 s. On the contrary, striated esophagus demonstrated absent or reduced peristalsis in response to ultra‐short (<2 s) intervals during straw‐facilitated multiple rapid swallows.Conclusions and inferencesStriated esophagus peristalsis is subject to manometrically observed inhibition during swallows with ultra‐short intervals. Inter‐swallow intervals as short as 5 s that inhibit smooth muscle esophagus peristalsis do not inhibit striated muscle peristalsis. The mechanisms of these observations are unknown but may relate to central or myenteric nervous system influences or the effects of pharyngeal biomechanics.