Klebsiella pneumoniae isolates causing liver abscess in Taiwan
Klebsiella pneumoniae isolates causing liver abscess in Taiwan
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DOI：
10.1016/s0732-8893(00)00157-7
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发表时间：
2000-08-01
影响因子：
2.9
通讯作者：
Luh, KT
中科院分区：
文献类型：
--
作者：
Chang, SC;Fang, CT;Luh, KT
与其他国家不同，1985年至1999年间，肺炎克雷伯菌一直是台湾化脓性肝脓肿的主要原因。本研究调查了 1993-1997 年间从台湾肝脓肿患者血培养中收集的 51 株肺炎克雷伯菌分离株的体外抗菌敏感性，并通过脉冲场凝胶电泳 (PFGE) 进行分型。所有 51 株分离株均对氨苄青霉素耐药，但对其他抗菌药物敏感。对第三代、第四代头孢菌素、单菌素、碳青霉烯类、环丙沙星的最低抑菌浓度（MIC）均小于1μg/ml。相比之下，来自无肝脓肿的社区获得性菌血症患者的 62 株肺炎克雷伯菌分离株具有相似的抗菌敏感性，而来自无肝脓肿的医院获得性菌血症患者的 142 株肺炎克雷伯菌分离株对所有测试的抗菌药物的敏感性要低得多。 PFGE分子流行病学分析发现，51个分离株中的20个属于8个遗传相关菌株簇，每个簇中有2个或3个分离株。其他 31 个分离株是遗传上不同的菌株。这项研究表明，在台湾引起肝脓肿的肺炎克雷伯菌分离株仍然对多种抗菌药物敏感，而且它们没有遗传相关性。 (C) 2000 Elsevier Science Inc. 保留所有权利。
Klebsiella pneumoniae has been the leading cause of pyogenic liver abscess in Taiwan during the period from 1985 to 1999, which is different from other countries. The present study investigated the in vitro antimicrobial susceptibilities of 51 K. pneumoniae isolates collected from blood cultures of patients with liver abscess in Taiwan during the period from 1993-1997, and typed by pulsed-field gel electrophoresis (PFGE). All 51 isolates were resistant to ampicillin, but susceptible to other antimicrobial agents. The minimum inhibitory concentrations (MICs) were less than 1 mu g/ml for the third- and fourth-generation cephalosporins, monobactam, carbapenems, and ciprofloxacin. In comparison, 62 isolates of K. pneumoniae from community-acquired bacteremic patients without liver abscess had similar antimicrobial susceptibilities, while 142 isolates from patients with hospital-acquired bacteremia without liver abscess were much less susceptible to all of the tested antimicrobial agents. PFGE molecular epidemiologic analysis found 20 out of 51 isolates belonged to eight clusters of genetically related strains, with two or three isolates in each clusters. The other 31 isolates were genetically distinct strains. This study demonstrated that K. pneumoniae isolates which cause liver abscess in Taiwan remained susceptible to a wide range of antimicrobial agents and that they were not genetically related. (C) 2000 Elsevier Science Inc. All rights reserved.