Bufadienolide and spirostanol glycosides from the rhizomes of helleborusorientalis.
Bufadienolide and spirostanol glycosides from the rhizomes of helleborusorientalis.
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DOI：
10.1021/np0203638
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发表时间：
2003-01
影响因子：
5.1
通讯作者：
Kazuki Watanabe;Y. Mimaki;H. Sakagami;Y. Sashida
中科院分区：
文献类型：
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作者：
Kazuki Watanabe;Y. Mimaki;H. Sakagami;Y. Sashida
分析了东方铁筷子根茎中蟾毒二烯苷和螺甾烷醇皂苷成分，分离出一种新的蟾毒二烯鼠李糖苷（1），沿着两种已知的蟾毒二烯苷（2和3）和五种新的螺甾烷醇皂苷（4-8）。新化合物的结构是在广泛的光谱分析的基础上确定的，包括2D NMR和水解裂解的结果。评价了分离的化合物对培养的肿瘤细胞和正常细胞的细胞毒活性。
The rhizomes of Helleborus orientalis have been analyzed for the bufadienolide glycoside and spirostanol saponin constituents, resulting in the isolation of a new bufadienolide rhamnoside (1), along with two known bufadienolide glycosides (2 and 3) and five new spirostanol saponins (4-8). The structures of the new compounds were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against cultured tumor and normal cells.