Nigrostriatal and mesolimbic control of sleep-wake behavior in rat
Nigrostriatal and mesolimbic control of sleep-wake behavior in rat
复制标题
黑质纹状体和中脑边缘对大鼠睡眠-觉醒行为的控制
DOI：
10.1007/s00429-019-01921-w
复制
发表时间：
2019-09-01
影响因子：
3.1
通讯作者：
Lu, Jun
中科院分区：
文献类型：
--
作者：
Qiu, Mei-Hong;Zhong, Zhi-Gang;Lu, Jun
通过背和腹侧纹状体的中脑多巴胺系统调节广泛的行为。为了剖析多巴胺能预测对背侧纹状体（鼻骨纹状体投影）和腹侧纹状体（中唇射的投影）在睡眠效果行为中的作用，我们选择性地化学刺激的nigrostion刺激的nigrostriatal或中间溶质预测并检查了对大鼠睡眠的影响。刺激性纹状体途径增加了睡眠和脑电图三角洲的功率，同时刺激中溶胶途径降低了睡眠和降低皮层脑电图的功率。这些结果表明，背侧或腹侧纹状体中的中脑多巴胺信号分别促进睡眠或唤醒。
The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.