Translational and clinical applications of salivary diagnostics.
Translational and clinical applications of salivary diagnostics.
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DOI：
10.1177/0022034511420434
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发表时间：
2011-10-01
影响因子：
--
通讯作者：
Malamud, D
中科院分区：
文献类型：
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作者：
Giannobile, W V;McDevitt, J T;Malamud, D
口腔生物标志物信号的检测技术（例如，蛋白质的elisa， RNA和DNA的PCR）以及微流控方法的工程和开发取得了重大进展，使基于口腔的护理点（POC）方法诊断局部和全身疾病成为现实。在本节中，我们将重点介绍三种这样的方法，即牙周病管理、系统性疾病的早期标志物和对药物基因组学研究有用的唾液标志物。使用非侵入性唾液样本和用户友好设备的新方法提供的结果与使用血液或尿液的实验室分析一样敏感和特异性。
There have been significant advances in techniques for the detection of biomarker signals in the oral cavity (e.g., ELISAs for proteins, PCR for RNA and DNA) as well as the engineering and development of microfluidic approaches to make oral-based point-of-care (POC) methods for the diagnosis for both local and systemic conditions a reality. In this section, we focus on three such approaches, namely, periodontal disease management, early markers for systemic diseases, and salivary markers useful for pharmacogenomic studies. Novel approaches using non-invasive, salivary samples and user-friendly devices offer results that are as sensitive and specific as laboratory-based analyses using blood or urine.