Thyroid antibodies and gestational diabetes mellitus: a meta-analysis
Thyroid antibodies and gestational diabetes mellitus: a meta-analysis
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甲状腺抗体和妊娠糖尿病：荟萃分析
DOI：
10.1016/j.fertnstert.2015.06.003
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发表时间：
2015-09-01
影响因子：
6.7
通讯作者：
Ma, Xu
中科院分区：
文献类型：
--
作者：
Yang, Ying;Li, Qian;Ma, Xu
目的：确定甲状腺抗体是否与孕妇妊娠期糖尿病（GDM）风险增加相关。设计：荟萃分析。设置：不适用。患者：20项涉及甲状腺抗体阳性孕妇的队列和病例对照研究是关注的暴露，GDM是结局。干预：无。主要结局指标：采用固定效应模型评估甲状腺抗体与GDM风险之间的关系。在不同类型的研究设计、不同的甲状腺抗体和特异性甲状腺功能障碍患者中进行亚组分析。结果：检索策略确定了167篇潜在相关的出版物，其中20篇纳入荟萃分析。甲状腺抗体和GDM之间的显着关联。对11项队列研究的荟萃分析表明，与参考组相比，妊娠早期甲状腺抗体阳性的孕妇没有明显的GDM风险。在亚组荟萃分析中，在甲状腺功能正常的孕妇中未发现甲状腺抗体与GDM之间存在显著关联，而在甲状腺功能障碍的妇女中发现了显著的正相关。根据目前可用的证据，甲状腺抗体与GDM风险之间存在显著但不强的相关性，妊娠早期的甲状腺抗体对GDM的风险缺乏预测价值。此外，甲状腺抗体可能不会增加甲状腺功能正常孕妇发生GDM的风险。(C)2015年，美国生殖医学会（American Society for Reproductive Medicine）
Objective: To determine whether thyroid antibodies are associated with an increased risk of gestational diabetes mellitus (GDM) in pregnant women.Design: Meta-analysis.Setting: Not applicable.Patient(s): Twenty cohort and case-control studies involving pregnant women with positive thyroid antibodies were the exposure of interest, and GDM was the outcome.Intervention(s): None.Main Outcome Measure(s): A fixed-effects model was used to evaluate the relationship between thyroid antibodies and the risk of GDM. Subgroup analyses were performed among different types of study design, different thyroid antibodies, and patients with specific thyroid dysfunction.Result(s): The search strategy identified 167 potentially relevant publications, of which 20 were included in the meta-analysis. A significant association between thyroid antibodies and GDM was observed. A meta-analysis of the 11 cohort studies with pregnant women with positive thyroid antibodies in their first trimester suggested no obvious risk of GDM compared with the reference group. In subgroup meta-analyses, no significant association between thyroid antibodies and GDM was found in euthyroid pregnant women, whereas a significant positive association was identified in women with a thyroid dysfunction.Conclusion(s): Based on the currently available evidence, there is a significant but not strong association between thyroid antibodies and the risk of GDM, and thyroid antibodies in the first trimester lack predictive value for the risk of GDM. In addition, thyroid antibodies may not increase the risk of GDM in euthyroid pregnant women. (C) 2015 by American Society for Reproductive Medicine.