Scale space calibrates present and subsequent spatial learning in Barnes maze in mice
Scale space calibrates present and subsequent spatial learning in Barnes maze in mice
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尺度空间校准小鼠巴恩斯迷宫中当前和随后的空间学习
DOI：
10.1101/2022.12.14.520510
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Imayoshi Itaru
中科院分区：
文献类型：
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作者：
Tachiki Yuto;Suzuki Yusuke;Kurahashi Mutsumi;Oki Keisuke;Mavuk ?zg?n;Nakagawa Takuma;Ishihara Shogo;Gyoten Yuichiro;Yamamoto Akira;Imayoshi Itaru
动物能够代表从较小到较大的不同尺度的空间。然而，大多数实验室动物生活在一个狭窄的范围内的规模空间，如家庭和实验设置，使得它很难推断的空间表示和学习过程中的大规模空间从那些在传统的规模空间。本研究设计了一个直径为3 m的巴恩斯迷宫（BM 3），探讨了巴恩斯迷宫（BM）中的空间学习是否受到尺度空间的校准。在BM 3中成功地建立了空间学习，其学习速率低于在常规的1-m直径巴恩斯迷宫（BM 1）中的学习速率。具体来说，探索策略的分析显示，在BM 3中的小鼠在整个学习过程中持续搜索某些地方，而这些地方在BM 1中迅速减少。这些结果表明，专用的探索策略，需要更多的试错和计算资源的BM 3比BM 1，导致BM 1和BM 3之间的空间学习的分歧。然后，我们探讨了先前的学习在一个BM规模校准随后的空间学习在另一个BM规模，并发现不对称的促进，使先前的学习在BM 3促进随后的BM 1学习，但反之亦然。因此，尺度空间校准当前和随后的BM学习。这是第一项证明小鼠BM中尺度依赖性空间学习的研究。BM 1和BM 3的组合将是一个合适的系统，以寻求动物如何用潜在的神经实现来表示不同的尺度空间。
Animals are capable of representing different scale spaces from smaller to larger ones. However, most laboratory animals live their life in a narrow range of scale spaces like homecages and experimental setups, making it hard to extrapolate the spatial representation and learning process in large scale spaces from those in conventional scale spaces. Here, we developed a 3-m diameter Barnes maze (BM3), then explored whether spatial learning in the Barnes maze (BM) is calibrated by scale spaces. Spatial learning in the BM3 was successfully established with a lower learning rate than that in a conventional 1-m diameter Barnes maze (BM1). Specifically, analysis of exploration strategies revealed that the mice in the BM3 persistently searched certain places throughout the learning, while such places were rapidly decreased in the BM1. These results suggest dedicated exploration strategies requiring more trial-and-errors and computational resources in the BM3 than in the BM1, leading to a divergence of spatial learning between the BM1 and the BM3. We then explored whether prior learning in one BM scale calibrates subsequent spatial learning in another BM scale, and found asymmetric facilitation such that the prior learning in the BM3 facilitated the subsequent BM1 learning, but not vice versa. Thus, scale space calibrates both the present and subsequent BM learning. This is the first study to demonstrate scale-dependent spatial learning in BM in mice. The couple of the BM1 and the BM3 would be a suitable system to seek how animals represent different scale spaces with underlying neural implementation.