Organization and maintenance of immunological memory by stroma niches
Organization and maintenance of immunological memory by stroma niches
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DOI：
10.1002/eji.200939500
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发表时间：
2009-08-01
影响因子：
5.4
通讯作者：
Radbruch, Andreas
中科院分区：
文献类型：
--
作者：
Tokoyoda, Koji;Zehentmeier, Sandra;Radbruch, Andreas
免疫记忆仍然是现代免疫学的谜团之一。我们对记忆细胞从其前体的产生、记忆细胞的生活方式或其维持、重新激活和终止知之甚少。在这里，我们讨论最近的证据，表明记忆性浆细胞（如本综述中所定义）和记忆性 Th 细胞维持在骨髓中，在由专用基质细胞组织的生存环境中休息（就增殖而言），这些细胞控制免疫记忆的稳态。
Immunological memory is still one of the enigmas of modern immunology. We poorly understand the generation of memory cells from their precursors, the lifestyle of memory cells or their maintenance, reactivation and termination. Here, we discuss the recent evidence suggesting that memory plasma cells, as defined in this review, and memory Th cells are maintained in the bone marrow, resting (in terms of proliferation) in survival niches organized by dedicated stroma cells, which control the homeostasis of immunological memory.