Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Possible implications for radiotherapy.
Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Possible implications for radiotherapy.
复制标题
人类黑色素瘤细胞系中的分数大小和潜在致命辐射损伤的修复。
DOI：
10.1148/radiology.142.1.7053535
复制
发表时间：
1982
期刊：
影响因子：
19.7
通讯作者：
J. Little
中科院分区：
文献类型：
--
作者：
R. Weichselbaum;A. Malcolm;J. Little
Studies performed on a human melanoma line in exponential growth showed radiation survival parameters similar to those of other tumors (n = 1.2, D0 = 151). In plateau-phase cultures, however, this tumor cell line was efficient in the repair of potentially lethal radiation damage, especially when large dose fractions were employed (there was a 48-fold recovery after 1,200 rad [12 Gy]). Thus, extrapolation from survival data generated only on exponentially growing cells may be misleading when determining the ultimate surviving fraction in some tumors. Large-fraction radiotherapy may not be effective in tumors that contain cells analogous to plateau-phase cells.
