Performance of oxygen delivery devices when the breathing pattern of respiratory failure is simulated
Performance of oxygen delivery devices when the breathing pattern of respiratory failure is simulated
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DOI：
10.1111/j.1365-2044.2008.05536.x
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发表时间：
2008-09-01
期刊：
影响因子：
10.7
通讯作者：
Hughes, M.
中科院分区：
文献类型：
--
作者：
Sim, M. A. B.;Dean, P.;Hughes, M.
氧气是医院最常用的处方药。吸入浓度随给氧流速、输送装置的特性和患者的呼吸模式而改变。我们以健康志愿者为研究对象，测量了在静息状态下和通过束缚受试者胸部模拟呼吸衰竭的呼吸模式，直到1秒内用力呼气量减少50%，呼吸频率为25次/分（-1）时，使用不同设备获得的吸入氧浓度。在这种呼吸模式下，在41岁时通过哈德森面罩给氧时，F(I)O(2)有统计学意义的下降。分钟(1)(23.8% (95% CI 17.4 -30.3%)减少),121年。min(-1)，加湿（17.8% （95% CI 8.8-26.7%）减少）和24.1min(-1)，加湿（12.2% （95% CI 5.0-19.3%）减少）。无呼吸（水库）面罩在15和110时无统计学意义的变化。min（-1）或在40℃下使用Vapotherm 2000i （TM）最小（-1），湿化，通过鼻尖。我们得出结论，当模拟呼吸衰竭的呼吸模式时，高流量装置输出的F(I)O(2)不受影响。非呼吸面罩在休息时达到的F(I)O(2)（0.68）低于文献中经常引用的值。
Oxygen is the commonest drug prescribed in hospitals. The inhaled concentration is altered by the administered oxygen flow rate, the characteristics of the delivery device and the patient's respiratory pattern. Using healthy volunteers we measured the inspired oxygen concentration achieved with different devices both at rest and when the breathing pattern of respiratory failure was simulated by binding the subjects' chests until the forced expiratory volume in 1 s was reduced by > 50% and the respiratory rate was > 25 breaths.min(-1). With this respiratory pattern, there was a statistically significant fall in F(I)O(2) while administering oxygen via a Hudson mask at 41.min(-1) (23.8% (95% CI 17.4-30.3%) reduction), 121.min(-1), humidified (17.8% (95% CI 8.8-26.7%) reduction) and 24.1min(-1), humidified (12.2% (95% CI 5.0-19.3%) reduction). There was no statistically significant change with a nonrebreathing (reservoir) mask at 15 and 110 1.min(-1) or with a Vapotherm 2000i (TM) at 40 1.min(-1), humidified, via nasal prongs. We conclude that the F(I)O(2) delivered by high flow devices is unaffected when the breathing pattern of respiratory failure is simulated. The F(I)O(2) achieved at rest by a nonrebreathing mask (0.68) is less than that often quoted in the literature.