Triplex radiometric, photoacoustic, and ultrasonic imaging based on single-pulse excitation.
Triplex radiometric, photoacoustic, and ultrasonic imaging based on single-pulse excitation.
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DOI：
10.1364/ol.387501
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发表时间：
2020-04-01
期刊：
影响因子：
3.6
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Zhao Y;Wang S;Merrill JA;Arellano JD;Trevisi LM;Li Y;Xiang L;Qu J;Liu L
在这封信中，我们提出了一种新的三参数检测方法，实现同时辐射，光声，超声成像的基础上单脉冲激励。通过分析光声信号和超声回波信号，可以同时获得光衰减、光吸收和声阻抗特性。为了验证该方法的可行性和准确性，对不同吸收系数和弹性系数的琼脂模型进行了测量。然后，通过对嵌入琼脂圆柱体中的叶骨架片进行成像来实验验证该方法。此外，通过离体猪耳组织的三重成像进行初步实验以表征软骨和周围组织。实验结果表明，该技术具有未来的潜力，可视化和提供生物组织的功能和结构信息。
In this Letter, we propose a novel triplex-parameter detection method to realize simultaneous radiometric, photoacoustic, and ultrasonic imaging based on single-pulse excitation. The optical attenuation, optical absorption, and acoustic impedance properties can be obtained simultaneously by analyzing the photoacoustic signals and the ultrasonic echo signals. To test the feasibility and accuracy of this method, agar phantoms with different absorption coefficients and elastic coefficients were measured. Then, this method was experimentally verified by imaging a leaf skeleton piece embedded in an agar cylinder. Furthermore, pilot experiments were performed by triplex imaging of pig ear tissue ex vivo to characterize the cartilage and surrounding tissue. Experimental results demonstrated that this technique has future potentials for visualizing and providing the functional and structural information of biological tissues.