Different coexpressions of arthritis-relevant genes between different body organs and different brain regions in the normal mouse population.
Different coexpressions of arthritis-relevant genes between different body organs and different brain regions in the normal mouse population.
复制标题
正常小鼠群体中不同身体器官和不同大脑区域之间关节炎相关基因的不同共表达。
DOI：
10.1016/j.gene.2012.12.054
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发表时间：
2013-02-25
期刊：
影响因子：
3.5
通讯作者：
Gu W
中科院分区：
文献类型：
--
作者：
Cao Y;Huang Y;Wang L;Zhu J;Gu W
据报道，类风湿性关节炎（RA）患者大脑不同部位的结构发生了变化。 RA 不被视为脑部疾病。脾脏和肺等身体器官产生 RA 相关基因。我们假设大脑结构的变化是由身体器官基因表达的变化引起的。大脑不同部位的变化可能受到不同身体器官基因表达改变的影响。这项研究探讨了器官或身体部位的基因表达之间的关联是否在不同的大脑结构中有所不同。通过检查正常小鼠群体中自发性关节炎小鼠模型中 10 个改变最大的基因的关联，我们发现了五个大脑结构和脾脏之间的两组基因表达模式。前额皮质、伏隔核和脾脏之间的关联模式相似，而大脑其他三个部分和脾脏之间的关联则表现出不同的模式。在身体器官与大脑结构之间关联的总体模式中，脾脏和肺具有相似的模式，肾脏和肝脏的模式相似。对另外五个已知的关节炎相关基因的分析产生了类似的结果。对 10 个不相关的关节炎基因的分析并未得出基因表达的强相关性或明显分离的模式。我们的数据表明，不同患病身体器官中的异常基因表达可能会影响不同大脑部分的结构变化。
Structural changes in different parts of the brain in rheumatoid arthritis (RA) patients have been reported. RA is not regarded as a brain disease. Body organs such as spleen and lung produce RA-relevant genes. We hypothesized that the structural changes in the brain are caused by changes of gene expression in body organs. Changes in different parts of the brain may be affected by altered gene expressions in different body organs. This study explored whether an association between gene expressions of an organ or a body part varies in different brain structures. By examining the association of the 10 most altered genes from a mouse model of spontaneous arthritis in a normal mouse population, we found two groups of gene expression patterns between five brain structures and spleen. The correlation patterns between prefrontal cortex, nucleus accumbens, and spleen were similar, while the associations between the other three parts of the brain and spleen showed a different pattern. Among overall patterns of the associations between body organs and brain structures, spleen and lung had a similar pattern, and patterns for kidney and liver were similar. Analysis of the five additional known arthritis-relevant genes produced similar results. Analysis of 10 nonrelevant-arthritis genes did not result in a strong association of gene expression or clearly segregated patterns. Our data suggest that abnormal gene expressions in different diseased body organs may influence structural changes in different brain parts.
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影响因子：
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影响因子：
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作者：
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影响因子：
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白细胞介素1受体拮抗剂缺陷小鼠自发性关节炎候选基因分析
影响因子：
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作者：
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通讯作者：
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