One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction.
One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction.
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DOI：
10.1016/j.jchf.2015.12.013
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Kitzman DW
中科院分区：
文献类型：
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作者：
Eggebeen J;Kim-Shapiro DB;Haykowsky M;Morgan TM;Basu S;Brubaker P;Rejeski J;Kitzman DW
测试相对低的单次剂量或一周的膳食无机硝酸盐剂量是否可以改善具有保留射血分数（HFPEF）的心力衰竭患者的运动耐量。运动不耐受是HFPEF的主要表现，主要是由于非心脏因素减少了活跃骨骼肌的氧气输送。最近的一项研究表明，单次急性剂量的甜菜根汁（BRJ， 12.9 mmol无机硝酸盐）改善了HFPEF患者的运动能力，而最近的另一项研究显示有机硝酸盐的中性和负面作用。20例HFPEF患者（年龄：69±7岁）被纳入初始交叉设计，比较单一急性剂量BRJ （6.1 mmol硝酸盐）和硝酸盐缺失安慰剂BRJ。第二阶段，每天给药一周，采用全治疗设计，患者平均服用BRJ 7天。该研究的主要结果是亚最大有氧耐力，以测量最大功率输出75%时的骑行时间来测量。没有与干预相关的不良事件。每日服用BRJ一周后，亚极限有氧耐力提高24% (p =0.02)，但与安慰剂相比，单次急性剂量BRJ不受影响。在两种给药方案中，BRJ的摄入显著降低了静息收缩压，并增加了血浆硝酸盐和亚硝酸盐。每日给药1周的BRJ （6.1 mmol无机硝酸盐）可显著改善老年HFPEF患者的亚极限有氧耐力和血压。
To test whether a relatively low single dose or week-long dosing of dietary inorganic nitrate can improve exercise tolerance in patients with Heart Failure with preserved ejection fraction (HFPEF). Exercise intolerance is the primary manifestation of HFPEF and is largely due to non-cardiac factors that reduce oxygen delivery to active skeletal muscles. A recent study showed improved exercise capacity in patients with HFPEF after a single, acute dose of beetroot juice (BRJ, 12.9 mmol inorganic nitrate) while another recent study showed neutral and negative effects of an organic nitrate. Twenty HFPEF patients (age: 69 ± 7 years) were enrolled in an initial cross-over design comparing a single, acute dose of BRJ (6.1 mmol nitrate) to a nitrate-depleted, placebo BRJ. A second, one week of daily dosing, phase employed an all-treated design in which patients consumed BRJ for an average of 7 days. The primary outcome of the study was submaximal aerobic endurance, measured as cycling time to exhaustion at 75% of measured maximal power output. No adverse events were associated with the intervention. Submaximal aerobic endurance improved 24% after one week of daily BRJ dosing (p =0.02), but was not affected by the single, acute dose of the BRJ compared to placebo. Consumption of BRJ significantly reduced resting systolic blood pressure and increased plasma nitrate and nitrite in both dosing schemes. One week of daily dosing with BRJ (6.1 mmol inorganic nitrate) significantly improves submaximal aerobic endurance and blood pressure in elderly HFPEF patients.