Contribution of non-ohnologous duplicated genes to high habitat variability in mammals
Contribution of non-ohnologous duplicated genes to high habitat variability in mammals
复制标题
非同源重复基因对哺乳动物高栖息地变异性的贡献
DOI：
10.1093/molbev/msu128
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发表时间：
2014
影响因子：
10.7
通讯作者：
Makino T.
中科院分区：
文献类型：
--
作者：
Tamate C.S.;Kawata M.;Makino T.
遗传系统影响环境适应的机制是生态学、进化论和生物保护等领域关注的焦点。然而，限制适应性进化的基因组特征仍然未知。最近的一项研究表明，果蝇全基因组中重复基因的比例与栖息地内的环境变异性相关，但目前尚不清楚，即使在基因组中包含大量由全基因组重复（WGD）产生的重复基因的脊椎动物中，是否也存在这种相关性。在这里，我们关注于在早期脊椎动物谱系中经历过WGD的哺乳动物基因组的全测序，并表明基因组中小规模重复（SSD）基因的比例与栖息地变异性显著相关，而不是WGD基因的比例。此外，低生境变异性的物种比高生境变异性的物种有更高的重复基因丢失比例，尤其是SSD基因。这些结果表明，生活在可变环境中的物种可能在其基因组中保留更多的SSD基因，并表明SSD基因对适应新环境和生存环境变化至关重要。这些见解可以应用于预测入侵和濒危物种。
The mechanism by which genetic systems affect environmental adaptation is a focus of considerable attention in the fields of ecology, evolution, and conservation. However, the genomic characteristics that constrain adaptive evolution have remained unknown. A recent study showed that the proportion of duplicated genes in wholeDrosophilagenomes correlated with environmental variability within habitat, but it remains unclear whether the correlation is observed even in vertebrates whose genomes including a large number of duplicated genes generated by whole-genome duplication (WGD). Here, we focus on fully sequenced mammalian genomes that experienced WGD in early vertebrate lineages and show that the proportion of small-scale duplication (SSD) genes in the genome, but not that of WGD genes, is significantly correlated with habitat variability. Moreover, species with low habitat variability have a higher proportion of lost duplicated genes, particularly SSD genes, than those with high habitat variability. These results indicate that species that inhabit variable environments may maintain more SSD genes in their genomes and suggest that SSD genes are important for adapting to novel environments and surviving environmental changes. These insights may be applied to predicting invasive and endangered species.