Chemically reactive intermediates and pulmonary xenobiotic toxicity.
Chemically reactive intermediates and pulmonary xenobiotic toxicity.
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DOI：
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发表时间：
1997-12
影响因子：
21.1
通讯作者：
T. E. Gram
中科院分区：
文献类型：
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作者：
T. E. Gram
在阅读这篇冗长的评论后，读者可能会认为试图总结本文所包含的数据是鲁莽的。如果是这样，作者和读者是完全雅阁的。我开始尽可能地将组织和细胞中的病理变化与化学、生物化学、分子、生物学和遗传学技术相结合，这些病理变化是通过光、扫描和TEM确定的。我并没有天真到把相关性等同于因果关系，但在实验生物学中，人们往往不得不依赖于一些相关性来暗示因果关系。这些数据也可以作为一个切入点，帮助研究者设计实验来支持/证实或反驳/反驳正在研究的假设。科学很少是非黑即白的白色，而是灰色的，年轻的研究者必须警惕那些过于大声、过于激烈或过于选择性地论证自己观点的科学家。科学中的真理常常是一个难解之结。
After reading this lengthy review, the reader may consider it foolhardy to attempt to summarize the data contained herein. If so, the author and the reader are in complete accord. I set out to integrate, wherever possible, pathological changes in tissues and cells as determined by light, scanning, and TEM with chemical, biochemical, molecular, biological, and genetic techniques. I am not so naive as to equate correlation with causation, but in experimental biology, one is often compelled to rely on a number correlations to suggest causation. These data may also act as a stepping-off point helping the investigator design experiments to support/confirm or refute/disprove the hypothesis under investigation. Science is rarely black and white but rather gray, and the young investigator must be wary of scientists who argue their points too vociferously, too loudly, or too selectively. The truth in science is often a Gordian knot.