MYOCARDIAL PERFUSION ABNORMALITIES IN ASYMPTOMATIC PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
MYOCARDIAL PERFUSION ABNORMALITIES IN ASYMPTOMATIC PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
复制标题
DOI：
10.1016/0002-9343(84)90704-6
复制
发表时间：
1984-01-01
影响因子：
5.9
通讯作者：
KLOSTER, FE
中科院分区：
文献类型：
--
作者：
HOSENPUD, JD;MONTANARO, A;KLOSTER, FE
系统性红斑狼疮年轻患者加速冠状动脉疾病和心肌梗塞的情况已有充分记录；然而，冠状动脉受累的患病率尚不清楚。因此，无论既往心脏病史如何，都选择了 26 名系统性狼疮患者进行运动 201T1 心脏闪烁扫描。 26 项研究中有 1 项（38.5%）存在节段性灌注异常。 5 名患者具有表明缺血的可逆性缺陷，4 名患者具有表明缺血的持续性缺陷，4 名患者具有与疤痕一致的持续性缺陷，1 名患者在 2 个区域同时具有可逆性和持续性缺陷。阳性T1结果与疾病持续时间、皮质类固醇治疗量、主要器官系统受累或年龄之间没有相关性。只有心包炎病史似乎与 201T1 阳性结果相关（P < 0.05）。节段性心肌灌注异常在系统性红斑狼疮患者中很常见。这是否反映了大血管冠状动脉疾病或小血管异常仍有待确定。
Accelerated coronary artery disease and myocardial infarction in young patients with systemic lupus erythematosus is well documented; however, the prevalence of coronary involvement is unknown. Accordingly, 26 patients with systemic lupus were selected irrespective of previous cardiac history to undergo exercise 201Tl cardiac scintigraphy. Segmental perfusion abnormalities were present in 1 of the 26 studies (38.5%). Five patients had reversible defects suggesting ischemia, 4 patients had persistent defects suggesting ischemia, 4 patients had persistent defects consistent with scar, and 1 patient had both reversible and persistent defects in 2 areas. There was no correlation between positive-Tl results and duration of disease, amount of corticosteroid treatment, major organ system involvement or age. Only a history of pericarditis appeared to be associated with positive 201Tl results (P < 0.05). Segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus. Whether this reflects large-vessel coronary disease or small-vessel abnormalities remains to be determined.