Cellular immune defects to Epstein-Barr virus-determined antigens in young males.
Cellular immune defects to Epstein-Barr virus-determined antigens in young males.
复制标题
年轻男性对 Epstein-Barr 病毒确定的抗原的细胞免疫缺陷。
作者：
M. Masucci;R. Szigeti;I. Ernberg;G. Masucci;G. Klein;J. Chessels;C. Sieff;S. Lie;A. Glomstein;L. Businco;W. Henle;G. Henle;G. Pearson;K. Sakamoto;D. Purtilo
三名男性与X-连锁淋巴细胞增生综合征（XLP）与低或无丙种球蛋白血症后EB病毒（EBV）感染和两名男性与慢性单核细胞增多症综合征进行了调查的免疫反应EBV确定的抗原。患有XLP的男性表现出严重的细胞免疫缺陷。在XLP患者中，自然杀伤细胞和干扰素激活的杀伤细胞活性的反应明显减少，对植物血凝素的白细胞迁移抑制反应受损。慢性单核细胞增多症的两名患者表现出不太严重的缺陷。通过白细胞迁移抑制测定，所有患者的EBV特异性免疫应答均显示部分或完全受损。在XLP男性患者中，针对EBV相关核抗原、早期抗原和病毒衣壳抗原的EBV特异性抗体显著减少。相反，慢性单核细胞增多症患者对大多数EBV特异性抗原的抗体升高。患有危及生命的EBV诱导的淋巴组织增生性疾病的个体可能表现出多种针对病毒的免疫机制缺陷。
Three males with the X-linked lymphoproliferative syndrome (XLP) with hypo- or agammaglobulinemia following Epstein-Barr virus (EBV) infection and two males with the chronic mononucleosis syndrome were investigated for immune responses to EBV-determined antigens. Males with XLP showed profound cellular immune defects. Markedly diminished responses of natural killer cell and interferon-activated killer cell activities and impaired leukocyte migration inhibition responses to phytohemagglutinin were determined in patients with XLP. The two patients with chronic mononucleosis showed less severe defects. All patients showed partial or complete impairment of their EBV-specific immune responses as measured by leukocyte migration inhibition. EBV-specific antibodies were markedly diminished against EBV-associated nuclear antigen, early antigen, and viral capsid antigen in males with XLP. In contrast, patients with chronic mononucleosis had elevated antibodies to most EBV-specific antigens. Individuals with life-threatening EBV-induced lymphoproliferative disorders may exhibit multiple defective immune mechanisms against the virus.