Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis.
Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis.
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DOI：
10.1016/j.clim.2015.07.005
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Steere AC
中科院分区：
文献类型：
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作者：
Pianta A;Drouin EE;Crowley JT;Arvikar S;Strle K;Costello CE;Steere AC
在这项研究中，在278名莱姆病患者中，有11%-15%的患者对Annexin A2有抗体反应，其中包括移行性红斑(EM)患者(疾病的早期症状)，以及抗生素敏感或抗生素耐药的莱姆关节炎(LA)患者(一种晚期疾病表现)。相反，只有在反应性或难治性LA患者中才能发现对膜联蛋白A2多肽有很强的T细胞反应性。在LA患者中，难治组Annexin A2蛋白水平较高，与血清和滑液中Annexin A2抗体水平相关。此外，在抗Annexin A2抗体阳性的抗生素耐药LA患者中，滑膜组织Annexin A2蛋白染色强烈，滑膜成纤维细胞增殖较多，组织纤维化较多。因此，一部分LA患者对膜联蛋白A2有T和B细胞反应，在难治性组中，膜联蛋白A2自身抗体与特定的病理结果相关。
In this study, autoantibody responses to annexin A2 were found in 11–15% of 278 patients with Lyme disease, including in those with erythema migrans (EM), an early sign of the illness, and in those with antibiotic-responsive or antibiotic-refractory Lyme arthritis (LA), a late disease manifestation. In contrast, robust T cell reactivity to annexin A2 peptides was found only in patients with responsive or refractory LA. In LA patients, annexin A2 protein levels, which were higher in the refractory group, correlated with annexin A2 antibody levels in sera and synovial fluid. In addition, in patients with antibiotic-refractory LA who had anti-annexin A2 antibodies, synovial tissue had intense staining for annexin A2 protein, greater synovial fibroblast proliferation and more tissue fibrosis. Thus, a subset of LA patients had T and B cell responses to annexin A2, and in the refractory group, annexin A2 autoantibodies were associated with specific pathologic findings.