VENOUS ADMIXTURE TO PULMONARY CIRCULATION IN HUMAN SUBJECTS BREATHING 100 PER CENT OXYGEN
VENOUS ADMIXTURE TO PULMONARY CIRCULATION IN HUMAN SUBJECTS BREATHING 100 PER CENT OXYGEN
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DOI：
10.1172/jci104739
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发表时间：
1963-01-01
影响因子：
15.9
通讯作者：
BANERJEE, CM
中科院分区：
文献类型：
--
作者：
SAID, SI;BANERJEE, CM
本文测定了6例正常人、15例慢性阻塞性肺气肿、14例弥漫性肺纤维化或浸润性病变、12例明显肥胖患者呼吸空气和吸100%氧气后的肺静脉混合液。与正常受试者相比，所有患者组的静脉混合液平均增加。深呼吸减少了肥胖患者的氧气分流，但对肺气肿或肺纤维化患者没有影响。氮气冲洗后残留的分流成分主要可以通过持续灌流肺泡来解释，这些肺泡是不通电的或不通风的，或者不允许氧气扩散。
Pulmonary venous admixture was determined during air breathing and after breathing 100% oxygen in 6 normal subjects, in 15 patients with chronic obstructive pulmonary emphysema, 14 with diffuse pulmonary fibrosis or infiltration, and 12 with marked obesity. All groups of patients demonstrated a mean increase in venous admixture relative to the normal subjects. Deep breathing reduced the shunt on oxygen in obese patients, but not in patients with emphysema or pulmonary fibrosis. The shunt component remaining after nitrogen washout could be explained largely by the continued perfusion of alveoli that were atelectatic or otherwise non-ventilated, or that permitted no oxygen diffusion.